Ion Channel Function During Oocyte Maturation and Fertilization.
Ion Channel Function During Oocyte Maturation and Fertilization.
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DOI：
10.3389/fcell.2018.00063
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发表时间：
2018
影响因子：
5.5
通讯作者：
Machaca K
中科院分区：
文献类型：
--
作者：
Carvacho I;Piesche M;Maier TJ;Machaca K
雄配子和雌配子的适当成熟对于支持受精和早期胚胎分裂是必不可少的。在卵巢中，未成熟的完全成熟的卵母细胞被阻止在减数分裂I的前期，不能支持受精。获得受精能力需要恢复减数分裂，这包括多个信号通路的重塑和细胞器的重组。总体而言，这种分化赋予卵子在受精时激活的能力，并促进卵子到胚胎的转变。卵母细胞的成熟与质膜电学性质的变化以及离子通道的功能和分布的变化有关。因此，在卵母细胞成熟过程中，离子通道和转运蛋白的表达、分布和功能的变化是生殖成功的基础。离子通道和转运体在膜电位调节中起重要作用，但在钙离子的情况下，它们在调节细胞内信号通路中也起着关键作用。在受精的背景下，钙离子已被证明是受精时普遍存在的发育激活剂，在与卵子激活和卵子到胚胎的转变相关的早期事件中发挥核心作用。这些早期事件包括多精受精受精受阻、减数分裂完成和向胚胎有丝分裂的过渡。本文就离子通道在卵母细胞成熟、受精和早期胚胎发育中的作用作一综述。我们将描述非洲爪哇卵母细胞中离子通道的研究如何转化为更好地理解离子通道在哺乳动物卵母细胞生理中的作用。
The proper maturation of both male and female gametes is essential for supporting fertilization and the early embryonic divisions. In the ovary, immature fully-grown oocytes that are arrested in prophase I of meiosis I are not able to support fertilization. Acquiring fertilization competence requires resumption of meiosis which encompasses the remodeling of multiple signaling pathways and the reorganization of cellular organelles. Collectively, this differentiation endows the egg with the ability to activate at fertilization and to promote the egg-to-embryo transition. Oocyte maturation is associated with changes in the electrical properties of the plasma membrane and alterations in the function and distribution of ion channels. Therefore, variations on the pattern of expression, distribution, and function of ion channels and transporters during oocyte maturation are fundamental to reproductive success. Ion channels and transporters are important in regulating membrane potential, but also in the case of calcium (Ca2+), they play a critical role in modulating intracellular signaling pathways. In the context of fertilization, Ca2+ has been shown to be the universal activator of development at fertilization, playing a central role in early events associated with egg activation and the egg-to-embryo transition. These early events include the block of polyspermy, the completion of meiosis and the transition to the embryonic mitotic divisions. In this review, we discuss the role of ion channels during oocyte maturation, fertilization and early embryonic development. We will describe how ion channel studies in Xenopus oocytes, an extensively studied model of oocyte maturation, translate into a greater understanding of the role of ion channels in mammalian oocyte physiology.
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影响因子：
4.6
作者：
Carvacho I;Ardestani G;Lee HC;McGarvey K;Fissore RA;Lykke-Hartmann K
通讯作者：
Lykke-Hartmann K
影响因子：
4
作者：
Bernhardt, Miranda L.;Zhang, Yingpei;Williams, Carmen J.
通讯作者：
Williams, Carmen J.
影响因子：
4.4
作者：
Bogeski, Ivan;Al-Ansary, Dalia;Peinelt, Christine
通讯作者：
Peinelt, Christine
影响因子：
4.1
作者：
Bobanovic, LK;Laine, M;Bootman, MD
通讯作者：
Bootman, MD
影响因子：
4
作者：
Bernhardt ML;Padilla-Banks E;Stein P;Zhang Y;Williams CJ
通讯作者：
Williams CJ