The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.
The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.
复制标题
DOI：
10.1016/j.schres.2009.09.008
复制
发表时间：
2009-12
影响因子：
4.5
通讯作者：
Kendler, Kenneth S.
中科院分区：
文献类型：
--
作者：
Riley, Brien;Kuo, Po-Hsiu;Maher, Brion S.;Fanous, Ayman H.;Sun, Jingchun;Wormley, Brandon;O'Neill, F. Anthony;Walsh, Dermot;Zhao, Zhongming;Kendler, Kenneth S.
在许多研究中，DTNBP1与精神分裂症有关，但相关的等位基因和单倍型因样本而异。我们评估了该基因中的9个单核苷酸多态(SNPs)与精神分裂症的关联，该样本来自爱尔兰，样本为1021例和626名对照。四个SNP提供了关联的证据(0.000018<；p<；0.045)，最强烈地与rs760761上的常见等位基因有关。5个标记的常见等位基因(包括rs760761)和rs2619538的次要等位基因重叠在DTNBP15‘端的单倍型也为关联提供了证据(p=0.0002)。二次分析表明，基于性别或家族史的关联信号没有差异。这些结果与最经常观察到的常见等位基因和常见等位基因单倍型的相关性是一致的，这是在之前的爱尔兰病例和对照研究中报告的，但在爱尔兰高密度家庭样本中没有报道。我们的结果不支持先前瑞典样本中有精神病家族病史的病例关联性增加的报告。对人类、黑猩猩和恒河猴的序列比较表明，rs760761在灵长类谱系中是一个特别可变的位置。这项研究从一个大的病例/对照样本中提供了常见的DTNBP1等位基因和单倍型与精神分裂症关联的进一步证据。
DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples. We assessed nine single nucleotide polymorphisms (SNPs) in this gene for association with schizophrenia in a new sample of 1021 cases and 626 controls from Ireland. Four SNPs give evidence of association (0.000018<p<0.045), most strongly with the common allele at rs760761. A haplotype of the common alleles of five markers (including rs760761) and the minor allele of rs2619538 overlapping the 5′ end of the DTNBP1 gene also gives evidence for association (p=0.0002). Secondary analyses showed no difference in the association signal based on sex or family history. These results are in agreement with the most consistently observed association with common alleles and common-allele haplotypes, reported in a previous study of Irish cases and controls but not in an Irish high-density family sample. Our results do not support the prior report from a Swedish sample of increased association in cases with a family history of psychotic illness. Comparison of human, chimpanzee and rhesus sequence suggest that rs760761 is a particularly variable position in the primate lineage. This study provides further evidence from a large case/control sample for association of common DTNBP1 alleles and haplotypes with schizophrenia.
登录
查看更多内容
影响因子：
11
作者：
Li, T;Zhang, F;Collier, DA
通讯作者：
Collier, DA
影响因子：
56.9
作者：
Gabriel, SB;Schaffner, SF;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
4.5
作者：
Liu, Chih-Min;Liu, Yu-Li;Hwu, Hai-Gwo
通讯作者：
Hwu, Hai-Gwo
影响因子：
0.9
作者：
Holliday, Elizabeth G.;Handoko, Herlina Y.;Nyholt, Dale R.
通讯作者：
Nyholt, Dale R.
DOI：
10.1186/1744-9081-3-50
发表时间：
2007-09-23
期刊：
Behavioral and brain functions : BBF
影响因子：
--
作者：
Datta SR;McQuillin A;Puri V;Choudhury K;Thirumalai S;Lawrence J;Pimm J;Bass N;Lamb G;Moorey H;Morgan J;Punukollu B;Kandasami G;Kirwin S;Sule A;Quested D;Curtis D;Gurling HM
通讯作者：
Gurling HM