Genetic susceptibility to vitiligo: Recent progress from genome-wide association studies
Genetic susceptibility to vitiligo: Recent progress from genome-wide association studies
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白癜风的遗传易感性：全基因组关联研究的最新进展
DOI：
10.1016/j.dsi.2014.09.004
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发表时间：
2014-12
影响因子：
2.5
通讯作者：
Leihong Flora Xiang
中科院分区：
文献类型：
--
作者：
Zheng Zhang;Leihong Flora Xiang
Generalized vitiligo (GV) is a complicated disease in which patchy depigmentation results from the autoimmune loss of melanocytes from affected regions. It may follow a pattern of polygenetic or multifactorial inheritance. Previously, a number of genetic susceptibility factors have been identified through linkage and candidate gene studies, such asHLA,PTPN22,NALP1, andXBP1. Recently, a series of genome-wide association studies have been carried out in different populations to further explore the susceptibility variants for GV. More than 30 robust susceptibility loci have been identified and confirmed. Most of these associated genes encode components of biological pathways reaching from the immune cell to the melanocytes. In this review, we summarize the advances of vitiligo epidemiology and genetics, and highlight recent findings from genome-wide association studies, emphasizing susceptibility loci and comparing the susceptibility loci between Chinese people and Caucasians. These genetic studies may help in providing an insight into the pathogenesis of this disease and initiating the feasibility of genetic diagnosis and personalized treatment for patients with GV in the future.
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影响因子：
4.4
作者：
Ochs, Hans D.;Gambineri, Eleonora;Torgerson, Troy R.
通讯作者：
Torgerson, Troy R.
启动子序列的遗传变异调节 XBP1 表达和白癜风的遗传风险。
影响因子：
4.5
作者：
Ren Y;Yang S;Xu S;Gao M;Huang W;Gao T;Fang Q;Quan C;Zhang C;Sun L;Liang Y;Han J;Wang Z;Zhang F;Zhou Y;Liu J;Zhang X
通讯作者：
Zhang X
影响因子：
30.8
作者：
通讯作者：
--
DOI：
10.1016/s0084-3954(09)79402-3
发表时间：
2010
期刊：
Yearbook of Pediatrics
影响因子：
--
作者：
J. Stockman
通讯作者：
J. Stockman
DOI：
10.7326/0003-4819-75-4-659_3
发表时间：
1971
期刊：
--
影响因子：
--
作者：
T. Fitzpatrick
通讯作者：
T. Fitzpatrick