Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
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为了鉴定类风湿关节炎（RA）的新型遗传危险因素（RA），我们对全基因组关联研究（GWAS）进行了5,539个自身抗体阳性病例和20,169个欧洲下降的控制，然后在6,768 RA的独立集中进行了复制。案例和8,806个对照。对所有41,282个样品的分析。这些新协会的协会将RA的总数带到了欧洲血统的31个11个SNP在P <0.05复制，其中许多经过验证的自动免疫风险等位基因，这表明大多数代表真正的RA风险等位基因。
To identify novel genetic risk factors for rheumatoid arthritis (RA), we conducted a genome-wide association study (GWAS) meta-analysis of 5,539 autoantibody positive RA cases and 20,169 controls of European descent, followed by replication in an independent set of 6,768 RA cases and 8,806 controls. Of 34 SNPs selected for replication, 7 novel RA risk alleles were identified at genome-wide significance (P<5×10−8) in analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5, and PXK. We also refined the risk alleles at two established RA risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed RA risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P<0.05, many of which are validated autoimmune risk alleles, suggesting that most represent bona fide RA risk alleles.
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影响因子：
30.8
作者：
Marchini, Jonathan;Howie, Bryan;Donnelly, Peter
通讯作者：
Donnelly, Peter
影响因子：
30.8
作者：
Barrett, Jeffrey C.;Clayton, David G.;Concannon, Patrick;Akolkar, Beena;Cooper, Jason D.;Erlich, Henry A.;Julier, Cecile;Morahan, Grant;Nerup, Jorn;Nierras, Concepcion;Plagnol, Vincent;Pociot, Flemming;Schuilenburg, Helen;Smyth, Deborah J.;Stevens, Helen;Todd, John A.;Walker, Neil M.;Rich, Stephen S.
通讯作者：
Rich, Stephen S.
影响因子：
3.5
作者：
Barton A;Eyre S;Ke X;Hinks A;Bowes J;Flynn E;Martin P;YEAR Consortium;BIRAC Consortium;Wilson AG;Morgan AW;Emery P;Steer S;Hocking LJ;Reid DM;Harrison P;Wordsworth P;Thomson W;Worthington J
通讯作者：
Worthington J
影响因子：
3.5
作者：
de Bakker, Paul I. W.;Ferreira, Manuel A. R.;Voight, Benjamin F.
通讯作者：
Voight, Benjamin F.
影响因子：
30.8
作者：
Barton A;Thomson W;Ke X;Eyre S;Hinks A;Bowes J;Plant D;Gibbons LJ;Wellcome Trust Case Control Consortium;YEAR Consortium;BIRAC Consortium;Wilson AG;Bax DE;Morgan AW;Emery P;Steer S;Hocking L;Reid DM;Wordsworth P;Harrison P;Worthington J
通讯作者：
Worthington J