The application of genomics to emerging zoonotic viral diseases.
The application of genomics to emerging zoonotic viral diseases.
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DOI：
10.1371/journal.ppat.1000557
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发表时间：
2009-10
期刊：
影响因子：
6.7
通讯作者：
Osterhaus AD
中科院分区：
文献类型：
--
作者：
Haagmans BL;Andeweg AC;Osterhaus AD
病原体的种间传播可能会导致人类以及家畜和野生动物出现新的传染病。基因组学工具，如高通量测序，mRNA表达谱，和基于微阵列的单核苷酸多态性分析提供了前所未有的方法来分析新兴病原体的基因组的多样性，以及宿主对它们的反应的分子基础。通过比较和对比新出现的感染与不同但相关的宿主物种中密切相关的病原体的结果，我们可以进一步描绘出决定人畜共患病传播和适应新入侵物种的结果的各种宿主途径。最终的挑战是将病原体和宿主基因组学数据与人畜共患病传播的生物学结果联系起来，并将综合数据转化为新型干预策略，最终能够有效控制新出现的传染病。
Interspecies transmission of pathogens may result in the emergence of new infectious diseases in humans as well as in domestic and wild animals. Genomics tools such as high-throughput sequencing, mRNA expression profiling, and microarray-based analysis of single nucleotide polymorphisms are providing unprecedented ways to analyze the diversity of the genomes of emerging pathogens as well as the molecular basis of the host response to them. By comparing and contrasting the outcomes of an emerging infection with those of closely related pathogens in different but related host species, we can further delineate the various host pathways determining the outcome of zoonotic transmission and adaptation to the newly invaded species. The ultimate challenge is to link pathogen and host genomics data with biological outcomes of zoonotic transmission and to translate the integrated data into novel intervention strategies that eventually will allow the effective control of newly emerging infectious diseases.
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影响因子：
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作者：
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作者：
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