Differential patterns of brain activation over time in adolescents with and without attention deficit hyperactivity disorder (ADHD) during performance of a sustained attention task.
Differential patterns of brain activation over time in adolescents with and without attention deficit hyperactivity disorder (ADHD) during performance of a sustained attention task.
复制标题
患有和不患有注意力缺陷多动障碍（ADHD）的青少年在执行持续注意力任务期间大脑激活随时间的差异模式。
DOI：
10.1055/s-0029-1220686
复制
发表时间：
2009-02
期刊：
影响因子：
1.4
通讯作者：
Holland S
中科院分区：
文献类型：
--
作者：
Epstein JN;Delbello MP;Adler CM;Altaye M;Kramer M;Mills NP;Strakowski SM;Holland S
最近的形态测量学研究表明，ADHD儿童可能表现出与非ADHD儿童相比的差异或延迟的大脑发育。此外，似乎受到影响的区域是控制注意力和执行功能的区域。本研究探讨了注意任务中大脑激活模式的发展过程。10名患有ADHD的青少年和14名正常对照者进行了一年两次的连续性能任务。在每个时间点收集fMRI扫描。在没有表现差异的情况下，ADHD儿童和正常对照儿童在初始测试中执行注意力任务时激活了额顶叶区域。一年后，正常对照组在执行相同的任务时没有任务相关的激活区域，而ADHD儿童在第二次测试时显示出较少的激活，但在第二次测试时继续在双侧额叶和左顶叶显示任务相关的激活。特别是，ADHD儿童似乎需要在相隔一年的测试期间继续使用右额中回，而正常对照组在第二次测试时没有激活该区域。ADHD儿童似乎在注意力任务中保持使用右前额叶区域，超出了正常对照组的观察范围。鉴于观察到相应的大脑区域的皮质变薄，未来的研究必须解决体积减少的相互影响，以及继续需要使用这些区域来执行基本的注意力任务。
Recent morphometric studies suggest that children with ADHD may demonstrate differential or delayed brain development than children without ADHD. Further, the regions that appear to be affected are regions that control attention and executive functioning. This study examines the developmental course of brain activation patterns during an attention task. Ten adolescents with ADHD and 14 normal controls performed a continuous performance task twice one year apart. fMRI scans were collected at each timepoint. In the absence of performance differences, children with ADHD and normal controls activated frontal-parietal regions while performing an attention task at initial testing. One year later, the normal control group evidenced no task-related areas of activation while performing the same task while the children with ADHD showed less activation at the second testing but continued to evidence task-related activations in bilateral frontal areas and left parietal lobe at the time of the second testing. In particular, children with ADHD appeared to require continued use of the right middle frontal gyrus during administration of testing one year apart while normal controls did not activate this region at the time of the second testing. Children with ADHD appear to maintain the use of right prefrontal regions during attentional tasks beyond what is observed among normal controls. Given observed cortical thinning in corresponding brain regions, future research must address the recipocal effects of volumetric reductions and a continued need for using these regions to perform basic attentional tasks.
登录
查看更多内容
影响因子：
7.6
作者：
Strakowski, SM;Adler, CM;DelBello, MP
通讯作者：
DelBello, MP
影响因子：
120.7
作者：
Castellanos, FX;Lee, PP;Rapoport, JL
通讯作者：
Rapoport, JL
影响因子：
5.4
作者：
Adler, CM;DelBello, MP;Strakowski, SM
通讯作者：
Strakowski, SM
影响因子：
17.7
作者：
Vaidya, CJ;Bunge, SA;Zalecki, CA
通讯作者：
Zalecki, CA
影响因子：
17.7
作者：
Tamm, Leanne;Menon, Vinod;Reiss, Allan L.
通讯作者：
Reiss, Allan L.