Gut Microbiota and Host Cometabolism Are Altered by Patiromer-Induced Changes in Serum and Stool Potassium.
Gut Microbiota and Host Cometabolism Are Altered by Patiromer-Induced Changes in Serum and Stool Potassium.
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肠道微生物群和宿主彗星被patiromer诱导的血清和粪便钾的变化改变。
DOI：
10.1016/j.ekir.2020.12.026
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发表时间：
2021-03
影响因子：
6
通讯作者：
Raj DS
中科院分区：
文献类型：
--
作者：
Gao B;Friedman ES;Regunathan R;Shrivastava A;Barrows IR;Amdur RL;Andrews SC;Barrows ED;Raj DS
高钾血症是晚期CKD患者常见且严重的电解质异常。1终末期肾病（ESRD）患者结肠钾（K+）排泄的适应性增加部分弥补了肾脏K+排泄的损失。2 Patiromer是一种非吸收性聚合物，可在整个胃肠道（GI）中结合K+，并导致血清K+水平降低。3有趣的是，K+对于某些细菌的生长、定植和毒力至关重要。因此，环境K+可能对肠道微生物群及其代谢功能产生显著影响。以前，我们已经研究了K+结合剂patiromer治疗对血液透析（HD）患者血清和粪便电解质的影响。6据我们所知，之前没有关于K+结合剂诱导的肠道K+含量变化对HD患者肠道微生物群和微生物群相关代谢物的影响的报道。在这项临床试验中，我们研究了通过patiromer降低血清K+对HD患者肠道微生物群落组成、功能能力和宿主彗星的影响。
Hyperkalemia is a common and serious electrolyte abnormality in advanced CKD patients. 1 Adaptive increase in colonic potassium (K+) excretion in patients with end-stage renal disease (ESRD) partially compensates for the loss of K+ excretion by the kidney. 2 Patiromer is a nonabsorbed polymer that binds K+ throughout the gastrointestinal (GI) tract and leads to lowering serum K+ levels. 3 Interestingly, K+ is essential for the growth, colonization, and virulence of some bacteria. 4, 5 Thus, ambient K+ could have a significant effect on gut microbiota and their metabolic function. Previously, we have examined the effect to K+ binder patiromer treatment on serum and stool electrolytes in hemodialysis (HD) patients. 6 To our knowledge, there have been no previous reports regarding the impact of K+ binder–induced changes in intestinal K+ content on the gut microbiota and microbiota-related metabolites in HD patients. In this clinical trial, we investigated the effect of lowering serum K+ by patiromer on the gut microbial community composition, their functional capacity, and host-cometabolism in HD patients.
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影响因子：
19.6
作者：
PANESE, S;MARTIN, RS;HAYSLETT, JP
通讯作者：
HAYSLETT, JP
影响因子：
3.4
作者：
Bianchi, Stefano;Aucella, Filippo;Regolisti, Giuseppe
通讯作者：
Regolisti, Giuseppe
影响因子：
19.6
作者：
Amdur, Richard L.;Paul, Rohan;Raj, Dominic S.
通讯作者：
Raj, Dominic S.
影响因子：
6.4
作者：
Price-Whelan A;Poon CK;Benson MA;Eidem TT;Roux CM;Boyd JM;Dunman PM;Torres VJ;Krulwich TA
通讯作者：
Krulwich TA
影响因子：
158.5
作者：
Weir, Matthew R.;Bakris, George L.;Pitt, Bertram
通讯作者：
Pitt, Bertram