Relationship between the serum GDF-15 concentration and muscle function in female patients receiving aortic valve replacement (TAVR, SAVR): Comparison with healthy elderly female subjects.
Relationship between the serum GDF-15 concentration and muscle function in female patients receiving aortic valve replacement (TAVR, SAVR): Comparison with healthy elderly female subjects.
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DOI：
10.1016/j.ijcha.2022.101032
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发表时间：
2022-06
影响因子：
2.9
通讯作者：
Toyoda, Shigeru
中科院分区：
文献类型：
--
作者：
Fukuda, Taira;Nakajima, Toshiaki;Yazawa, Hiroko;Hirose, Suguru;Yokomachi, Jun;Kato, Takashi;Nishikawa, Riichi;Koshiji, Nobuo;Tokura, Michiaki;Nasuno, Takahisa;Nishino, Setsu;Obi, Syotaro;Shibasaki, Ikuko;Kanaya, Tomoaki;Nakamura, Fumitaka;Fukuda, Hirotsugu;Abe, Shichiro;Sakuma, Masashi;Toyoda, Shigeru
心血管手术患者的骨钙素减少与术后预后密切相关。生长分化因子(GDF)-15参与心血管疾病的发病机制。我们研究了主动脉瓣置换术患者和健康老年受试者血清GDF-15浓度与肌肉功能的关系。43例行主动脉瓣膜手术的女性患者，年龄(79.9±66.4)岁；经导管主动脉瓣置换术(TAVR)19例，常规外科主动脉瓣置换术(SAVR)24例；健康老年女性(75.9±66.1)岁。通过多频生物电阻抗分析仪测量步行速度、握力和骨骼肌质量指数(SMI)，以确定是否存在骨质疏松症。采用双抗体夹心法测定患者术前血清GDF-15浓度。主动脉瓣置换术患者血浆GDF15水平明显高于健康老年人(主动脉瓣置换术：1624g/mLvs健康对照组：955pg/mL±368pg/mL，p<0.001)。多元线性回归分析显示，即使在调整了年龄后，血清GDF15水平也独立于高敏C反应蛋白水平和表皮生长因子受体决定了握力(β=-0.318，p=0.025)。12.5%的健康老年人、83.3%的TAVR患者和64.3%的SAVR患者存在骨质疏松症。在包括接受主动脉瓣置换术的患者中，定义石棺减少的GDF-15浓度为1109微克/毫升。行主动脉瓣膜置换术的女性患者术前血清GDF-15浓度高于健康老年患者，可能是骨质疏松症的一个血清标志物。
Sarcopenia is closely associated with postoperative prognosis in patients undergoing cardiovascular surgery. Growth differentiation factor (GDF)-15 is involved in the pathogenesis of cardiovascular disease. We examined the relationship between the serum GDF-15 concentration and muscle function in patients receiving aortic valve replacement and healthy elderly subjects. Forty-three female patients undergoing aortic valve surgery (79.9 ± 6.4 years; transcatheter aortic valve replacement [TAVR] n = 19, conventional surgical aortic valve replacement [SAVR] n = 24) and 64 healthy elderly female subjects (75.9 ± 6.1 years) were included. Walking speed, grip strength, and skeletal muscle mass index (SMI) by a multifrequency bioelectrical impedance analyzer were measured to determine the presence of sarcopenia. Preoperative serum GDF-15 concentration was measured by enzyme-linked immunosorbent assay. The GDF-15 level was higher in patients receiving aortic valve replacement than in healthy elderly subjects (aortic valve replacement: 1624 ± 1186 pg/mL vs. healthy: 955 ± 368 pg/mL, p < 0.001). Multivariate linear regression analysis showed that the serum GDF-15 level determined grip strength independently of the high-sensitivity C-reactive protein level and eGFR, even after adjusting for age (β = -0.318, p = 0.025). Sarcopenia was found in 12.5% of healthy elderly subjects, 83.3% of patients with TAVR, and 64.3% of patients with SAVR. The GDF-15 concentration that defined sarcopenia was 1109 pg/mL in subjects including patients receiving aortic valve replacement. The preoperative serum GDF-15 concentration, which was higher in female patients receiving aortic valve replacement than in healthy elderly subjects, may be a serum marker of sarcopenia.
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DOI：
10.1016/j.ijcha.2020.100651
发表时间：
2020-12
期刊：
International journal of cardiology. Heart & vasculature
影响因子：
--
作者：
Yazawa H;Fukuda T;Kaneda H;Waku R;Sakuma M;Matsumoto A;Toyoda S;Abe S;Nakamura F;Inoue T;Nakajima T
通讯作者：
Nakajima T
影响因子：
39.3
作者：
Fuelster, Susann;Tacke, Matthias;von Haehling, Stephan
通讯作者：
von Haehling, Stephan
影响因子：
37.8
作者：
Shimura, Tetsuro;Yamamoto, Masanori;Hayashida, Kentaro
通讯作者：
Hayashida, Kentaro
影响因子：
158.5
作者：
Mack, M. J.;Leon, M. B.;Smith, C. R.
通讯作者：
Smith, C. R.
影响因子：
10
作者：
Garfield, Benjamin E.;Crosby, Alexi;Kemp, Paul R.
通讯作者：
Kemp, Paul R.