ADHD May Associate With Reduced Tolerance to Acute Subconcussive Head Impacts: A Pilot Case-Control Intervention Study.
ADHD May Associate With Reduced Tolerance to Acute Subconcussive Head Impacts: A Pilot Case-Control Intervention Study.
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DOI：
10.1177/1087054720969977
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发表时间：
2022-01
影响因子：
3
通讯作者：
Kawata K
中科院分区：
文献类型：
--
作者：
Nowak MK;Ejima K;Quinn PD;Bazarian JJ;Mickleborough TD;Harezlak J;Newman SD;Kawata K
为了验证我们的假设，即ADHD患者对10个足球头引起的亚震荡头部撞击的弹性会降低。我们在51名成人（20.6 ± 1.7岁）中进行了病例对照干预研究。使用ImPACT进行认知评估，并测量神经递质-光（NF-L）、Tau、胶质细胞酸性蛋白（GFAP）和泛素-C-末端水解酶-L1（UCH-L1）的血浆水平。10个控制足球标题表现出ADHD特定的语言记忆功能的短暂下降。10个标题也减弱了ADHD组视觉记忆功能的学习效果，而非ADHD组即使在10个标题之后也改善了言语和视觉记忆功能。ADHD组的血液生物标志物水平对10个标题引起的应激敏感，其中血浆GFAP和UCH-L1水平在10个标题后急剧升高。在ADHD组中，ADHD特异性文字记忆下降的差异与血浆GFAP水平的增加相关。这些数据表明，ADHD可能会降低大脑对重复亚震荡头部撞击的耐受性。
To test our hypothesis that individuals with ADHD would exhibit reduced resiliency to subconcussive head impacts induced by ten soccer headings. We conducted a case-control intervention study in 51 adults (20.6 ± 1.7 years old). Cognitive assessment, using ImPACT, and plasma levels of neurofilament-light (NF-L), Tau, glial-fibrillary-acidic protein (GFAP), and ubiquitin-C-terminal hydrolase-L1 (UCH-L1) were measured. Ten controlled soccer headings demonstrated ADHD-specific transient declines in verbal memory function. Ten headings also blunted learning effects in visual memory function in the ADHD group while the non-ADHD counterparts improved both verbal and visual memory functions even after ten headings. Blood biomarker levels of the ADHD group were sensitive to the stress induced by ten headings, where plasma GFAP and UCH-L1 levels acutely increased after 10 headings. Variance in ADHD-specific verbal memory decline was correlated with increased levels of plasma GFAP in the ADHD group. These data suggest that ADHD may reduce brain tolerance to repetitive subconcussive head impacts.
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影响因子：
8.2
作者：
Kawata, Keisuke;Liu, Charles Y.;Merkel, Steven F.;Ramirez, Servio H.;Tierney, Ryan T.;Langford, Dianne
通讯作者：
Langford, Dianne
DOI：
10.1249/mss.0b013e3182793067
发表时间：
2013-04-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
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通讯作者：
Collins, Michael W.
影响因子：
48
作者：
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通讯作者：
Jagoda, Andy S.
影响因子：
4.1
作者：
Joseph, Jacob R.;Swallow, Jennylee S.;Broglio, Steven P.
通讯作者：
Broglio, Steven P.
影响因子：
18.4
作者：
McCrory, Paul;Meeuwisse, Willem;Vos, Pieter E.
通讯作者：
Vos, Pieter E.