Microfluidic fabrication of microparticles for biomedical applications.

Microfluidic fabrication of microparticles for biomedical applications.
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用于生物医学应用的微粒的微流体制造

DOI:
10.1039/c7cs00263g
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发表时间:
2018-07-30
影响因子:
46.2
通讯作者:
Weitz DA
Weitz DA
中科院分区:
化学1区
文献类型:
--
作者:
Li W ;Zhang L ;Ge X ;Xu B ;Zhang W ;Qu L ;Choi CH ;Xu J ;Zhang A ;Lee H ;Weitz DA

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液滴微流体提供了对微尺度多流体流动的精细控制,使以高通量方式制造具有精确可调结构和组成的先进微粒子成为可能。这些显著的特征与合适的材料和制备方法相结合,使得活性物质能够高效、直接地包裹在微粒中,其特征和功能可以很好地控制。这些微粒在广泛的生物相关应用中具有巨大的潜力,包括药物输送、细胞基质、生物传感器,甚至作为人工细胞。本文对液滴微流体制备的材料、制备方法和微粒结构进行了简要的综述。我们还全面概述了它们在生物医学应用中的最新应用。最后,我们讨论了存在的挑战和展望,以促进这些工程微粒的未来发展。
Droplet microfluidics offers exquisite control over the flows of multiple fluids in microscale, enabling fabrication of advanced microparticles with precisely tunable structures and compositions in a high throughput manner. The combination of these remarkable features with proper materials and fabrication methods has enabled high efficiency, direct encapsulation of actives in microparticles whose features and functionalities can be well controlled. These microparticles have great potential in a wide range of bio-related applications including drug delivery, cell-laden matrices, biosensors and even as artificial cells. In this review, we briefly summarize the materials, fabrication methods, and microparticle structures produced with droplet microfluidics. We also provide a comprehensive overview of their recent uses in biomedical applications. Finally, we discuss the existing challenges and perspectives to promote the future development of these engineered microparticles.
DOI: 10.1039/b813405g
发表时间: 2008-01-01
期刊: LAB ON A CHIP
影响因子: 6.1
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