Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study
Association Between Funisitis and Childhood Intellectual Development: A Prospective Cohort Study
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滑膜炎与儿童智力发展之间的关联：一项前瞻性队列研究
DOI：
10.3389/fneur.2019.00612
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发表时间：
2019-06
影响因子：
3.4
通讯作者：
Zhang Yongjun
中科院分区：
文献类型：
--
作者：
Liu Chengbo;Chen Yan;Zhao Dongying;Zhang Jun;Zhang Yongjun
背景：以前的研究表明，产前炎症可能会损害早产儿未成熟的大脑。在这项研究中，我们的目的是探讨尿道炎是否会影响儿童神经发育。我们假设儿童神经发育在患有或没有尿道炎的人群中会有所不同。材料和方法：使用美国围产期合作项目（1959-1976）的数据，对29,725名具有可用智商（IQ）的受试者进行了研究。根据质量控制程序的标准方案进行了详细的胎盘检查。在调整混杂因素后，应用多变量logistic回归模型评估4岁或7岁时尿道炎与智商之间的关系。结果：早期早产儿伴尿道炎患儿在4岁时有3.0倍（95%可信区间1.2,7.3）的低全量表智商（<70）风险，直到7岁才消失。足月出生的患有尿道炎的儿童在7岁时出现低表现智商的风险为1.9倍（95%可信区间为1.2,3.0），但他们出现低全面智商的风险并未增加。晚期早产儿的智商得分没有差异。结论：尿道炎可能损害幼儿发育中的大脑，导致幼儿4岁时智商相对较低，但仅对7岁时的表现智商有负面影响。
Background: Previous studies have suggested that prenatal inflammation could damage the immature brain of preterm infants. In this study, we aimed to investigate whether funisitis could affect childhood neurodevelopment. We hypothesized that childhood neurodevelopment would vary across groups with or without funisitis. Material sand Methods: Using data from the U.S. Collaborative Perinatal Project (1959–1976), 29,725 subjects with available intelligence quotient (IQ) were studied. Detailed placental examinations were conducted according to a standard protocol with quality control procedures. Multivariate logistic regression models were applied to evaluate the relationship between funisitis and IQ at age 4 or 7 years after adjusting for confounders. Results: Early preterm birth children with funisitis had a 3.0-fold (95% confidence interval 1.2, 7.3) risk of low full-scale IQ (<70) at age 4 years, which disappeared until age 7 years. Term birth children with funisitis had 1.9-fold (95% confidence interval 1.2, 3.0) risk of low performance IQ at age 7 years, but they did not have increased risk of low full-scale IQ. No difference in IQ score was found in late preterm birth children. Conclusion: Funisitis may injure the developmental brain of infants, leading to the relative low IQ in childhood at age 4, but the negative effect is only existed in performance IQ at age of 7.
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影响因子：
14.5
作者：
Watkins, KE;Vargha-Khadem, F;Gadian, DG
通讯作者：
Gadian, DG
影响因子：
3.6
作者：
Jenster, Meike;Bonifacio, Sonia L.;Ruel, Theodore;Rogers, Elizabeth E.;Tam, Emily W.;Partridge, John Colin;Barkovich, Anthony James;Ferriero, Donna M.;Glass, Hannah C.
通讯作者：
Glass, Hannah C.
影响因子：
2.9
作者：
Anwar, Muhammad Nabeel;Navid, Muhammad Samran;Kitajo, Keiichi
通讯作者：
Kitajo, Keiichi
影响因子：
5.4
作者：
MYRIANTHOPOULOS, NC;FRENCH, KS
通讯作者：
FRENCH, KS
影响因子：
6.6
作者：
Brown, Alan S.;Patterson, Paul H.
通讯作者：
Patterson, Paul H.