Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems.
Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems.
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DOI：
10.3390/pharmaceutics15112623
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发表时间：
2023-11-14
期刊：
影响因子：
5.4
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Wang Z;Wang X;Xu W;Li Y;Lai R;Qiu X;Chen X;Chen Z;Mi B;Wu M;Wang J
仿生递送系统(BDSS)受到生物系统复杂设计的启发，已经成为纳米医学中的一种开创性范式，在治疗递送方面提供了无与伦比的优势。这些系统包括脂质体、基于蛋白质的纳米颗粒、胞外囊泡和多糖等平台，因其定向递送、最大限度地减少副作用和增强治疗效果而受到称赞。然而，BDSS从研究环境到临床应用的转换充满了挑战，包括重复性问题、生理稳定性以及严格的疗效和安全性评估。此外，BDSS的创新性质要求重新评估和发展现有的监管和道德框架。这篇综述概述了BDSS，深入探讨了多方面的翻译挑战和新出现的解决方案，并通过真实世界的案例研究强调了这一点。强调BDSS重新定义医疗保健的潜力，我们倡导持续的跨学科合作和研究。随着我们对生物系统了解的加深，BDSS在临床翻译中的未来似乎很有希望，重点是个性化的药物和精致的患者特定的递送系统。
Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems, have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled advantages in therapeutic delivery. These systems, encompassing platforms such as liposomes, protein-based nanoparticles, extracellular vesicles, and polysaccharides, are lauded for their targeted delivery, minimized side effects, and enhanced therapeutic outcomes. However, the translation of BDSs from research settings to clinical applications is fraught with challenges, including reproducibility concerns, physiological stability, and rigorous efficacy and safety evaluations. Furthermore, the innovative nature of BDSs demands the reevaluation and evolution of existing regulatory and ethical frameworks. This review provides an overview of BDSs and delves into the multifaceted translational challenges and present emerging solutions, underscored by real-world case studies. Emphasizing the potential of BDSs to redefine healthcare, we advocate for sustained interdisciplinary collaboration and research. As our understanding of biological systems deepens, the future of BDSs in clinical translation appears promising, with a focus on personalized medicine and refined patient-specific delivery systems.
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影响因子：
1.7
作者：
通讯作者：
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影响因子：
5.2
作者：
Saxena A;Rubens M;Ramamoorthy V;Zhang Z;Ahmed MA;McGranaghan P;Das S;Veledar E
通讯作者：
Veledar E
影响因子：
5.2
作者：
Aljabali, Alaa A. A.;Bakshi, Hamid A.;Tambuwala, Murtaza M.
通讯作者：
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DOI：
10.1016/j.msec.2013.01.001
发表时间：
2013-05-01
影响因子：
7.9
作者：
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通讯作者：
Abel Lozano-Perez, A.
DOI：
10.1016/b978-0-08-101750-0.00014-3
发表时间：
2018-01-01
期刊：
ENGINEERING OF BIOMATERIALS FOR DRUG DELIVERY SYSTEMS: BEYOND POLYETHYLENE GLYCOL
影响因子：
--
作者：
Abbina, Srinivas;Parambath, Anilkumar
通讯作者：
Parambath, Anilkumar