Expression of Piezo mRNA is unaffected in a rat model of knee osteoarthritis.
Expression of Piezo mRNA is unaffected in a rat model of knee osteoarthritis.
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DOI：
10.1177/17448069211014059
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发表时间：
2021-01
期刊：
影响因子：
3.3
通讯作者：
Saito M
中科院分区：
文献类型：
--
作者：
Ikeda R;Arimura D;Saito M
膝骨关节炎会损害受影响者的日常生活活动。其对膝关节的不可逆退行性改变会引起功能障碍和令人不快的关节痛。疼痛具有炎症成分，通常表现为机械性异常性疼痛和痛觉过敏。持续负重和关节运动会增加膝骨关节炎的疼痛敏感性。了解机械性异常性疼痛和痛觉过敏的机制可能为缓解具有此类症状的患者的疼痛提供治疗目标。压电通道是机械激活的离子通道，可能参与关节软骨的机械转导。尽管已经表明炎症增强了机械刺激诱导的压电通道电流，但压电表达水平是否受到膝骨关节炎的影响仍不清楚。在使用碘乙酸钠建立大鼠膝骨关节炎模型后，我们测量了膝关节和背根神经节中的Piezo mRNA，发现Piezo mRNA水平没有上调。这一发现提出了一个问题：压电通道是否以及如何参与骨关节炎中机械引起的疼痛。
Osteoarthritis of the knee impairs activities of daily living of those affected. Its irreversible degenerative changes to the knee joint induce functional disturbance and unpleasant arthralgia. The pain has inflammatory components and often is manifested with mechanical allodynia and hyperalgesia. Sustained weight bearing and joint movements increase pain sensitivity in knee osteoarthritis. Understanding the mechanisms underlying the mechanical allodynia and hyperalgesia might provide a therapeutical target for pain relief in patients with such symptoms. Piezo channel is a mechanically activated ion channel that may be involved in mechanical transduction in the articular cartilage. Although it has been shown that inflammation potentiates Piezo channel current induced by mechanical stimulation, whether Piezo expression levels are influenced by knee osteoarthritis has remained unknown. We measured Piezo mRNA in knee joints and dorsal root ganglia after establishing a model of knee osteoarthritis in rats using monosodium iodoacetate and found Piezo mRNA level is not upregulated. This finding raises a question as whether and how Piezo channels may be involved in mechanically induced pain in osteoarthritis.
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