Auditory extinction and spatio-temporal order judgment in patients with left- and right-hemisphere lesions
Auditory extinction and spatio-temporal order judgment in patients with left- and right-hemisphere lesions
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左右半球病变患者的听觉消退和时空顺序判断
DOI：
10.1016/j.neuropsychologia.2012.01.029
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发表时间：
2012
期刊：
影响因子：
2.6
通讯作者：
Rübsamen
中科院分区：
文献类型：
--
作者：
Dörrscheidt;Cramon;D.Y. von ;Rübsamen
通过系统地操纵自由场条件下双侧刺激的起始时间，对获得性脑损伤患者的听觉消退和时空顺序判断（STOJ）进行了评估。我们测试了这一假设，即灭绝将减少增加刺激的起始时间。研究了两组右半球（RH，n=17）或左半球（LH，n=17）损伤的患者，并与健康对照组（n=12）进行了比较。这些患者是根据先前诊断的损伤招募的：由于皮质和/或皮质下颞顶中心病变导致的听觉辨别缺陷伴（RHE/LHE）或不伴消退（RH 0/LH 0）。刺激在声学自由场中双侧呈现，起始时间为±30至± 150 ms，或单侧呈现，来自位于±60°的扬声器。低频（LF）和高频（HF）刺激被用来解决空间听觉处理在水平面的基础上的两个主要线索的耳间时间和耳间强度差异，分别。受试者的任务是指出他们是否感知到一个（左或右）或两个（左和右）刺激，并在两个情况下做出STOJ（左或右优先）。在那些先前表现出双侧同时刺激（RHE/LHE）消退的患者中，颞叶震颤显著降低了消退。此外，他们在STOJ中的错误率高于对照组。许多患者在双侧同时刺激（RH 0/LH 0）中没有消退迹象，也显示出STOJ受损：在RH 0患者中，这是特异于同病灶主导刺激，而在LH 0患者中，未观察到副作用。数据支持的概念，两个半球的时空听觉感知的差异作用，并讨论了普遍的模式灭绝和可能的长期减少。
Auditory extinction and spatio-temporal order judgment (STOJ) were assessed in patients with acquired brain damage by systematically manipulating onset times in bilateral stimulation under free-field conditions. We tested the hypothesis that extinction will be reduced by increasing stimulus onset asynchrony. Two groups of patients with right-hemisphere (RH, n=17) or left-hemisphere (LH, n=17) damage were investigated in comparison to a healthy control group (n=12). The patients were recruited based on previously diagnosed impairments: auditory discrimination deficits with (RHE/LHE) or without extinction (RH0/LH0) due to cortical and/or subcortical temporo-parietally centred lesions. Stimuli were presented bilaterally in the acoustic free-field, with an onset asynchrony of ±30 to ±150ms, or unilaterally, from speakers located ±60°. Low frequency (LF) and high frequency (HF) stimuli were used to address spatial auditory processing in the horizontal plane based on the two main cues of interaural time and interaural intensity differences, respectively. The subjects’ task was to indicate whether they perceived one (left or right) or two stimuli (left and right), and in the case of two make an STOJ (left or right first). Temporal asynchrony significantly reduced extinction in those patients that previously exhibited extinction for bilateral-simultaneous stimulation (RHE/LHE). In addition, their error rates in STOJ were higher than the controls’. A number of patients with no previous signs of extinction in bilateral-simultaneous stimulation (RH0/LH0) also showed impaired STOJ: in RH0patients this was specific to ipsilesional-leading stimuli, whilst in LH0patients no side-specific effect was observed. The data support the notion of differential roles for the two hemispheres in spatio-temporal auditory perception and are discussed with respect to prevalent models of extinction and its possible long-term reduction.
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