Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression.
Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression.
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麻疹病毒诱导人血液树突状细胞前体成熟与免疫抑制有关。
DOI：
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发表时间：
1997
影响因子：
11.1
通讯作者：
Schaulies
中科院分区：
文献类型：
--
作者：
Jens;J. Schnorr;S. Xanthakos;P. Keikavoussi;E. Kämpgen;V. Meulen;Sibylle Schneider;Schaulies
除了诱导针对再感染的保护性免疫应答外，急性麻疹还与针对重复感染因子和回忆抗原的免疫功能的显著抑制相关，并且这种关联是目前与麻疹病毒（MV）感染相关的高发病率和死亡率的主要原因。树突状细胞（DCs）是抗原呈递细胞，其在初次和二次免疫应答的启动中起关键作用，因此我们开始定义MV与这些细胞的相互作用。我们发现，从外周血单核细胞产生的成熟和前体人DC表达主要MV蛋白受体CD 46，并且对MV疫苗（艾德）和野生型（WTF）菌株的感染高度敏感，尽管具有不同的动力学。除CD 46表达下调外，MV感染后成熟DCs表面重要功能抗原的表达模式无明显改变。然而，前体DC在WTF感染后24 h内和艾德感染后72 h内上调HLA-DR、CD 83和CD 86，表明它们的功能成熟。此外，艾德和WTF感染后，DC中白细胞介素12的合成显著增强。另一方面，MV感染的DC强烈干扰体外新鲜分离的外周血淋巴细胞的丝裂原依赖性增殖。这些数据表明，DC的效应功能的分化并没有受到损害，而是受到MV感染的刺激。然而，表达MV表面抗原的成熟、活化的DC确实提供抑制淋巴细胞增殖的负信号，从而有助于MV诱导的免疫抑制。
As well as inducing a protective immune response against reinfection, acute measles is associated with a marked suppression of immune functions against superinfecting agents and recall antigens, and this association is the major cause of the current high morbidity and mortality rate associated with measles virus (MV) infections. Dendritic cells (DCs) are antigen-presenting cells crucially involved in the initiation of primary and secondary immune responses, so we set out to define the interaction of MV with these cells. We found that both mature and precursor human DCs generated from peripheral blood monocytic cells express the major MV protein receptor CD46 and are highly susceptible to infection with both MV vaccine (ED) and wild-type (WTF) strains, albeit with different kinetics. Except for the down-regulation of CD46, the expression pattern of functionally important surface antigens on mature DCs was not markedly altered after MV infection. However, precursor DCs up-regulated HLA-DR, CD83, and CD86 within 24 h of WTF infection and 72 h after ED infection, indicating their functional maturation. In addition, interleukin 12 synthesis was markedly enhanced after both ED and WTF infection in DCs. On the other hand, MV-infected DCs strongly interfered with mitogen-dependent proliferation of freshly isolated peripheral blood lymphocytes in vitro. These data indicate that the differentiation of effector functions of DCs is not impaired but rather is stimulated by MV infection. Yet, mature, activated DCs expressing MV surface antigens do give a negative signal to inhibit lymphocyte proliferation and thus contribute to MV-induced immunosuppression.
DOI：
10.1073/pnas.93.6.2588
发表时间：
1996-03-19
影响因子：
11.1
作者：
Zhou, LJ;Tedder, TF
通讯作者：
Tedder, TF
麻疹病毒抑制丝裂原诱导的 T 细胞增殖，但不会直接干扰细胞内 T 细胞的激活过程。
影响因子：
3.7
作者：
Yanagi,Y;Cubitt,BA;Oldstone,MB
通讯作者：
Oldstone,MB
麻疹病毒对 T 淋巴细胞功能的抑制是由于细胞周期停滞在 G1 期。
DOI：
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发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
McChesney,MB;Altman,A;Oldstone,MB
通讯作者：
Oldstone,MB