VaximmutorDB: A Web-Based Vaccine Immune Factor Database and Its Application for Understanding Vaccine-Induced Immune Mechanisms.
VaximmutorDB: A Web-Based Vaccine Immune Factor Database and Its Application for Understanding Vaccine-Induced Immune Mechanisms.
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DOI：
10.3389/fimmu.2021.639491
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发表时间：
2021
影响因子：
7.3
通讯作者：
He Y
中科院分区：
文献类型：
--
作者：
Berke K;Sun P;Ong E;Sanati N;Huffman A;Brunson T;Loney F;Ostrow J;Racz R;Zhao B;Xiang Z;Masci AM;Zheng J;Wu G;He Y
疫苗刺激对保护性免疫应答至关重要的各种免疫因子。然而，疫苗诱导的免疫因素和途径的全面情况尚未系统地收集和分析。为了解决这个问题，我们开发了VaximmutorDB，这是一个基于网络的疫苗免疫因子（简称“vaximmutors”）数据库系统，从同行评议的文章中手动管理。VaximmutorDB目前存储了来自13种宿主物种的1，740种疫苗免疫因子（例如，人、小鼠和猪）。这些vaximutors是由46种病原体的154种疫苗诱导的。前10名vaximmutors包括三种抗体（IgG、IgG 2a和IgG 1）、Th 1免疫因子（IFN-γ和IL-2）、Th 2免疫因子（IL-4和IL-6）、TNF-α、CASP-1和TLR 8。许多丰富的主机进程（例如，刺激性C型凝集素受体信号传导途径，靶向膜的SRP依赖性共翻译蛋白）和细胞组分（例如，细胞外外泌体、核质）。使用流感作为模型，活的减毒和灭活的流感疫苗刺激许多共有的途径，例如许多白细胞介素（包括IL-1、IL-4、IL-6、IL-13、IL-20和IL-27）的信号传导、干扰素信号传导、MARK 1活化和中性粒细胞脱粒。然而，他们也提出了自己独特的反应模式。流感减毒活疫苗FluMist诱导了显著的信号转导应答，灭活流感疫苗Fluarix诱导了显著的蛋白质代谢应答。两项不同的黄热病疫苗（YF-Vax）研究导致了重叠的基因列表;然而，它们共享的途径部分比基因列表多。有趣的是，活的减毒YF-Vax模拟了蛋白质应答的显著代谢，这与杀死的灭活Fluarix诱导的模式相似。生成了一个用户友好的Web界面来访问、浏览和搜索VaximmutorDB数据库信息。作为第一个基于Web的疫苗免疫因子数据库，VaximmutorDB提供了系统的收集，标准化，存储和分析实验验证的疫苗免疫因子，支持更好地了解保护性疫苗免疫。
Vaccines stimulate various immune factors critical to protective immune responses. However, a comprehensive picture of vaccine-induced immune factors and pathways have not been systematically collected and analyzed. To address this issue, we developed VaximmutorDB, a web-based database system of vaccine immune factors (abbreviated as “vaximmutors”) manually curated from peer-reviewed articles. VaximmutorDB currently stores 1,740 vaccine immune factors from 13 host species (e.g., human, mouse, and pig). These vaximmutors were induced by 154 vaccines for 46 pathogens. Top 10 vaximmutors include three antibodies (IgG, IgG2a and IgG1), Th1 immune factors (IFN-γ and IL-2), Th2 immune factors (IL-4 and IL-6), TNF-α, CASP-1, and TLR8. Many enriched host processes (e.g., stimulatory C-type lectin receptor signaling pathway, SRP-dependent cotranslational protein targeting to membrane) and cellular components (e.g., extracellular exosome, nucleoplasm) by all the vaximmutors were identified. Using influenza as a model, live attenuated and killed inactivated influenza vaccines stimulate many shared pathways such as signaling of many interleukins (including IL-1, IL-4, IL-6, IL-13, IL-20, and IL-27), interferon signaling, MARK1 activation, and neutrophil degranulation. However, they also present their unique response patterns. While live attenuated influenza vaccine FluMist induced significant signal transduction responses, killed inactivated influenza vaccine Fluarix induced significant metabolism of protein responses. Two different Yellow Fever vaccine (YF-Vax) studies resulted in overlapping gene lists; however, they shared more portions of pathways than gene lists. Interestingly, live attenuated YF-Vax simulates significant metabolism of protein responses, which was similar to the pattern induced by killed inactivated Fluarix. A user-friendly web interface was generated to access, browse and search the VaximmutorDB database information. As the first web-based database of vaccine immune factors, VaximmutorDB provides systematical collection, standardization, storage, and analysis of experimentally verified vaccine immune factors, supporting better understanding of protective vaccine immunity.
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影响因子：
32.4
作者：
Bronner DN;Abuaita BH;Chen X;Fitzgerald KA;Nuñez G;He Y;Yin XM;O'Riordan MX
通讯作者：
O'Riordan MX
DOI：
10.1038/nri2569
发表时间：
2009-07
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Geijtenbeek TB;Gringhuis SI
通讯作者：
Gringhuis SI
影响因子：
3.6
作者：
Diehl, S;Rincón, M
通讯作者：
Rincón, M
影响因子：
1.9
作者：
Lin Y;He Y
通讯作者：
He Y
影响因子：
3.6
作者：
Brennan, MA;Cookson, BT
通讯作者：
Cookson, BT