Ontology representation and analysis of vaccine formulation and administration and their effects on vaccine immune responses.
Ontology representation and analysis of vaccine formulation and administration and their effects on vaccine immune responses.
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DOI：
10.1186/2041-1480-3-17
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发表时间：
2012-12-20
影响因子：
1.9
通讯作者：
He Y
中科院分区：
文献类型：
--
作者：
Lin Y;He Y
疫苗是一种加工材料，如果施用，能够刺激适应性免疫应答以预防或改善疾病。疫苗接种过程可以保护宿主免于随后暴露于感染因子，并导致疾病减少或疾病的完全预防。疫苗配方和接种方法可能会显著影响疫苗的安全性和有效性。在本报告中，在疫苗本体（VO）的框架内使用OWL表示疫苗组分和疫苗给药过程的详细分类和定义。不同的使用案例展示了不同的疫苗配方和疫苗接种途径如何影响疫苗接种后的保护效力、一般免疫应答和不良事件。例如，采用腹膜内或鼻内给药对小鼠接种牛种布氏杆菌疫苗株RB 51导致不同的保护水平。美国FDA提供的疫苗不良事件数据显示，减毒活疫苗和非活疫苗通常采用不同的给药途径，具有不同的局部和全身不良反应表现。疫苗制剂和给药途径可独立或协同影响接种后的宿主应答结果（阳性保护性免疫或不良事件）。在这两个领域的不同疫苗和疫苗接种因素的本体表示允许更好地理解和分析不同因素和免疫应答之间的因果关系。
A vaccine is a processed material that if administered, is able to stimulate an adaptive immune response to prevent or ameliorate a disease. A vaccination process may protect the host against subsequent exposure to an infectious agent and result in reduced disease or total prevention of the disease. Vaccine formulation and administration methods may affect vaccine safety and efficacy significantly. In this report, the detailed classification and definitions of vaccine components and vaccine administration processes are represented using OWL within the framework of the Vaccine Ontology (VO). Different use cases demonstrate how different vaccine formulations and routes of vaccine administration affect the protection efficacy, general immune responses, and adverse events following vaccination. For example, vaccinations of mice with Brucella abortus vaccine strain RB51 using intraperitoneal or intranasal administration resulted in different protection levels. As shown in the vaccine adverse event data provided by US FDA, live attenuated and nonliving vaccines are usually administered in different routes and have different local and systematic adverse effect manifestations. Vaccine formulation and administration route can independently or collaboratively affect host response outcomes (positive protective immunity or adverse events) after vaccination. Ontological representation of different vaccine and vaccination factors in these two areas allows better understanding and analysis of the causal effects between different factors and immune responses.
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影响因子：
12.3
作者：
通讯作者：
--
影响因子：
46.9
作者：
Smith, Barry;Ashburner, Michael;Lewis, Suzanna
通讯作者：
Lewis, Suzanna
影响因子：
82.9
作者：
Brockstedt, DG;Bahjat, KS;Dubensky, TW
通讯作者：
Dubensky, TW
影响因子：
3.7
作者：
Sarntivijai, Sirarat;Xiang, Zuoshuang;He, Yongqun
通讯作者：
He, Yongqun
影响因子：
6.7
作者：
Finn, A
通讯作者：
Finn, A