Mechanobiology of neural development.
Mechanobiology of neural development.
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DOI：
10.1016/j.ceb.2020.05.012
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发表时间：
2020-10
影响因子：
7.5
通讯作者：
Pathak MM
中科院分区：
文献类型：
--
作者：
Abuwarda H;Pathak MM
随着大脑的发育，增殖的细胞组织成结构、分化、迁移、伸出长的过程，并与其他细胞连接。这些生物过程产生机械力，进一步塑造细胞动力学和器官模式。发育生物学中一个尚未解答的主要问题是细胞如何检测和转导发育过程中产生的机械力以影响发育的生化和遗传程序。这种知识差距源于对细胞力学的分子参与者缺乏了解以及缺乏测量和操纵组织中机械力的技术。在这篇综述文章中，我们研究了开始消除这些瓶颈的最新进展，并重点介绍了揭示机械力在神经发育过程中作用的新方法的结果。
As the brain develops, proliferating cells organize into structures, differentiate, migrate, extrude long processes, and connect with other cells. These biological processes produce mechanical forces that further shape cellular dynamics and organ patterning. A major unanswered question in developmental biology is how the mechanical forces produced during development are detected and transduced by cells to impact biochemical and genetic programs of development. This gap in knowledge stems from a lack of understanding of the molecular players of cellular mechanics and an absence of techniques for measuring and manipulating mechanical forces in tissue. In this review article we examine recent advances that are beginning to clear these bottlenecks, and highlight results from new approaches that reveal the role of mechanical forces in neurodevelopmental processes.
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DOI：
10.1073/pnas.1700934114
发表时间：
2017-06-27
影响因子：
11.1
作者：
Galea, Gabriel L.;Cho, Young-June;Copp, Andrew J.
通讯作者：
Copp, Andrew J.
影响因子：
2.7
作者：
DESMOND, ME;JACOBSON, AG
通讯作者：
JACOBSON, AG
影响因子：
25
作者：
Koser DE;Thompson AJ;Foster SK;Dwivedy A;Pillai EK;Sheridan GK;Svoboda H;Viana M;Costa LD;Guck J;Holt CE;Franze K
通讯作者：
Franze K
影响因子：
64.8
作者：
Barriga EH;Franze K;Charras G;Mayor R
通讯作者：
Mayor R
影响因子：
5.9
作者：
Ellefsen, Kyle L.;Holt, Jesse R.;Pathak, Medha M.
通讯作者：
Pathak, Medha M.