Melvin
Melvin
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梅尔文
DOI：
10.2307/j.ctv224tvx4.6
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
J. Lipka
中科院分区：
文献类型：
--
作者：
J. Lipka
孕期抗逆转录病毒治疗(ART)的前瞻性、多中心、观察性研究--参与艾滋病临床试验小组方案5084的孕妇所生婴儿的宫内蛋白水解酶抑制物(PI)治疗对脐血血脂的影响。方法：对80名接受抗病毒药物治疗的孕妇所生婴儿和73名接受其他抗逆转录病毒药物治疗的孕妇所生婴儿的临床结局进行分析。对其中117例新生儿脐带血清进行总低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、胆固醇、甘油三酯、载脂蛋白A1(ApoA1)、载脂蛋白B100(ApoB)和脂蛋白(A)的检测。分析中考虑的协变量包括种族/民族、胎龄、婴儿性别、婴儿出生体重、分娩方式、母亲吸烟和饮酒、产后体重指数和ART持续时间。结果：两组脐血总胆固醇、高密度脂蛋白胆固醇、甘油三酯、载脂蛋白A1、载脂蛋白B、载脂蛋白(A)及载脂蛋白B/载脂蛋白A1比值无明显差异。这些感染艾滋病毒的婴儿的脐带血血脂水平与其他新生儿队列中报告的水平相似。在控制种族/民族因素后，接受PIs治疗的妇女所生婴儿的低密度脂蛋白胆固醇高于未接受PIs治疗的妇女所生婴儿的低密度脂蛋白(29 mg/dl比27 mg/dl，P=0.006)。结论：子宫内PI暴露的婴儿脐血中只有低密度脂蛋白胆固醇显著高于未暴露于PI的婴儿。由于两组之间的差异很小，母亲PI治疗对婴儿出生时低密度脂蛋白水平的影响的临床相关性尚不清楚。原创文章
protease inhibitor (PI) therapy in utero on cord blood lipids in infants born to mothers enrolled in AIDS Clinical Trials Group protocol 5084, a prospective, multicentre, observational study of antiretroviral therapy (ART) during pregnancy. Methods: Clinical outcome was determined in 80 infants born to women treated with PIs and 73 infants born to women treated with other antiretrovirals during pregnancy. Cord blood serum from 117 of these infants was assayed for total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglyceride, apolipoprotein A1 (apoA1), apolipoprotein B100 (apoB) and lipoprotein (a). Covariates considered in the analysis included race/ethnicity, gestational age, infant gender, infant birth weight, mode of delivery, maternal tobacco and alcohol use, post-partum body mass index, and ART duration. Results: Cord blood total and HDL cholesterol, triglyceride, apoA1, apoB, lipoprotein (a) and apoB/apoA1 ratio were not different between the two groups. Cord blood lipid levels in these HIV-exposed infants were similar to those reported in other neonatal cohorts. Controlling for race/ethnicity, infants born to women treated with PIs had higher LDL cholesterol than those born to women not treated with PIs (29 mg/dl versus 27 mg/dl, P=0.006). Conclusion: Only LDL cholesterol was significantly higher in the cord blood of PI-exposed infants versus those not exposed to PIs in utero. As the difference between the two groups was small, the clinical relevance of the effect of maternal PI treatment on infant LDL cholesterol levels at birth is not clear. Original article
孕期母亲吸毒与母亲艾滋病毒培养阳性和围产期艾滋病毒传播之间的关系。
DOI：
10.1097/00002030-199603000-00006
发表时间：
1996
期刊：
AIDS (London, England)
影响因子：
--
作者：
Rodriguez,EM;Mofenson,LM;Chang,BH;Rich,KC;Fowler,MG;Smeriglio,V;Landesman,S;Fox,HE;Diaz,C;Green,K;Hanson,IC
通讯作者：
Hanson,IC
影响因子：
120.7
作者：
Riddler, SA;Smit, E;Kingsley, LA
通讯作者：
Kingsley, LA