The origin of mechanical harmonic distortion within the organ of Corti in living gerbil cochleae.
The origin of mechanical harmonic distortion within the organ of Corti in living gerbil cochleae.
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DOI：
10.1038/s42003-021-02540-0
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发表时间：
2021-08-25
影响因子：
5.9
通讯作者：
Ren T
中科院分区：
文献类型：
--
作者：
He W;Ren T
Although auditory harmonic distortion has been demonstrated psychophysically in humans and electrophysiologically in experimental animals, the cellular origin of the mechanical harmonic distortion remains unclear. To demonstrate the outer hair cell-generated harmonics within the organ of Corti, we measured sub-nanometer vibrations of the reticular lamina from the apical ends of the outer hair cells in living gerbil cochleae using a custom-built heterodyne low-coherence interferometer. The harmonics in the reticular lamina vibration are significantly larger and have broader spectra and shorter latencies than those in the basilar membrane vibration. The latency of the second harmonic is significantly greater than that of the fundamental at low stimulus frequencies. These data indicate that the mechanical harmonics are generated by the outer hair cells over a broad cochlear region and propagate from the generation sites to their own best-frequency locations. He and Ren measured sub-nanometer vibrations of the reticular lamina from the apical ends of the outer hair cells in living gerbil cochleae using a custom-built low-coherence interferometer. Their results indicate that mechanical harmonics are generated by the motile outer hair cells and can propagate to their best-frequency locations.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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