Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis.

Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis.
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DOI:
10.1016/j.ymgme.2017.07.008
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发表时间:
2017-11
影响因子:
3.8
通讯作者:
Sakamoto KM
Sakamoto KM
中科院分区:
生物学2区
文献类型:
--
作者:
Wilkes MC;Repellin CE;Sakamoto KM

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非编码核糖核酸(ncRNA)在生物学中的作用目前是一个备受关注的领域。造血需要快速变化的调节分子来引导适当的分化,ncRNA非常适合于此。这并不奇怪,几乎所有的造血方面的ncRNA分配给他们的作用,无疑更多的等待表征。干细胞维持、淋巴样、髓样和红系分化均受各种ncRNA调节,包括微RNA(miRNA)、长链非编码RNA(lncRNA)和基因组内的各种转座因子。随着我们对许多复杂的ncRNA作用的理解不断增长,新的发现正在挑战现有的分类方案。在这篇综述中,我们简要概述了大类的ncRNA和讨论了几个例子调节正常和异常造血。
The role of non-coding Ribonucleic Acids (ncRNAs) in biology is currently an area of intense focus. Hematopoiesis requires rapidly changing regulatory molecules to guide appropriate differentiation and ncRNA are well suited for this. It is not surprising that virtually all aspects of hematopoiesis have roles for ncRNAs assigned to them and doubtlessly much more await characterization. Stem cell maintenance, lymphoid, myeloid and erythroid differentiation are all regulated by various ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and various transposable elements within the genome. As our understanding of the many and complex ncRNA roles continues to grow, new discoveries are challenging the existing classification schemes. In this review we briefly overview the broad categories of ncRNAs and discuss a few examples regulating normal and aberrant hematopoiesis.
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