The prevalence, child characteristics, and maternal risk factors for the continuum of fetal alcohol spectrum disorders: A sixth population-based study in the same South African community.
The prevalence, child characteristics, and maternal risk factors for the continuum of fetal alcohol spectrum disorders: A sixth population-based study in the same South African community.
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DOI：
10.1016/j.drugalcdep.2020.108408
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发表时间：
2021-01-01
影响因子：
4.2
通讯作者：
Hoyme HE
中科院分区：
文献类型：
--
作者：
May PA;Marais AS;De Vries MM;Buckley D;Kalberg WO;Hasken JM;Stegall JM;Hedrick DM;Robinson LK;Manning MA;Tabachnick BG;Seedat S;Parry CDH;Hoyme HE
胎儿酒精谱系障碍 (FASD) 的患病率和特征此前已在该社区进行过描述。在一项新的横断面研究中，采用主动病例确定方法，采用修订后的医学研究所标准，对一年级学生（n = 735）进行畸形检查和神经行为评估。他们的母亲接受了有关危险因素的采访。最终诊断是通过结构化病例会议分配的。患有胎儿酒精综合症（FAS）、部分FAS（PFAS）和酒精相关神经发育障碍（ARND）的儿童在所有主要变量、多种畸形特征和神经行为表现上均与对照组显着不同。患有 FASD 儿童的母亲报告在怀孕前和怀孕期间饮酒量显着增加（患有 FAS 儿童的母亲报告怀孕前每个饮酒日 (DDD) 饮酒 7.8 (±6.1) 杯，怀孕后每天饮酒 5.1 (±5.9) 杯）。 FASD 连续体诊断的远端风险变量为： 母亲身高、体重和体重指数较低；较高的重力；教育程度和家庭收入较低；以及后来怀孕的认可。酒精和烟草仍然是唯一常用的药物。报告孕早期饮酒两次 DDD 的女性生出患有 FASD 孩子的可能性是不饮酒者的 13 倍（95% CI：8.1–32.7）；那些报告在整个怀孕期间饮酒的人生下患有 FASD 的孩子的可能性高出 19.4 倍 (95% CI:8.2–46.0)。在该社区进行首次研究 17 年后，FASD 患病率仍然高达 16% 至 31%。 FAS 率可能有所下降，但 PFAS 和 ARND 率似乎稳定在较高水平。
Prevalence and characteristics of fetal alcohol spectrum disorders (FASD) have been described previously in this community. Active case ascertainment methods were employed in a new cross-sectional study with Revised Institute of Medicine criteria among first grade students (n=735) via dysmorphology examinations and neurobehavioral assessments. Their mothers were interviewed regarding risk factors. Final diagnoses were assigned via structured case conferences. Children with fetal alcohol syndrome (FAS), partial FAS (PFAS), and alcohol related-neurodevelopmental disorder (ARND) were significantly different from controls on all cardinal variables, multiple dysmorphology traits and neurobehavioral performance. Mothers of children with FASD reported significantly more drinking before and during pregnancy (mothers of children with FAS reported 7.8 (±6.1) drinks per drinking day (DDD) prior to pregnancy and 5.1 (±5.9) after pregnancy recognition). Distal risk variables for a diagnosis on the continuum of FASD were: lower maternal height, weight, and body mass index; higher gravidity; lower education and household income; and later pregnancy recognition. Alcohol and tobacco remain the only commonly used drugs. Women reporting first trimester drinking of two DDD were 13 times more likely (95% CI:8.1–32.7) to have a child with FASD than non-drinkers; and those who reported drinking throughout pregnancy were 19.4 times more likely (95% CI:8.2–46.0) to have a child with FASD. Seventeen years after the first study in this community, FASD prevalence remains high at 16% to 31%. The FAS rate may have declined somewhat, but rates of PFAS and ARND seemed to plateau, at a high rate.
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DOI：
10.1111/acer.14325
发表时间：
2020-06
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Coles, Claire D.;Kalberg, Wendy;Kable, Julie A.;Tabachnick, Barbara;May, Philip A.;Chambers, Christina D.
通讯作者：
Chambers, Christina D.
DOI：
10.1002/ajmg.a.37023
发表时间：
2015-04
期刊：
American journal of medical genetics. Part A
影响因子：
--
作者：
Hoyme HE;Hoyme DB;Elliott AJ;Blankenship J;Kalberg WO;Buckley D;Abdul-Rahman O;Adam MP;Robinson LK;Manning M;Bezuidenhout H;Jones KL;May PA
通讯作者：
May PA
影响因子：
8
作者：
Hoyme, H. Eugene;Kalberg, Wendy O.;May, Philip A.
通讯作者：
May, Philip A.
影响因子：
2.9
作者：
ABEL, EL
通讯作者：
ABEL, EL
DOI：
10.1016/j.jpeds.2016.06.047
发表时间：
2016-10
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Goh PK;Doyle LR;Glass L;Jones KL;Riley EP;Coles CD;Hoyme HE;Kable JA;May PA;Kalberg WO;Sowell ER;Wozniak JR;Mattson SN
通讯作者：
Mattson SN