Insight Into Regulatory T Cells in Sepsis-Associated Encephalopathy.
Insight Into Regulatory T Cells in Sepsis-Associated Encephalopathy.
复制标题
深入了解脓毒症相关脑病中的调节性 T 细胞
DOI：
10.3389/fneur.2022.830784
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发表时间：
2022
影响因子：
3.4
通讯作者：
Chai YF
中科院分区：
文献类型：
--
作者：
Gao YL;Liu YC;Zhang X;Shou ST;Chai YF
脓毒症相关性脑病(SAE)是一种脓毒症期间弥漫性中枢神经系统(CNS)功能障碍，与脓毒症患者死亡率增加和预后不良有关。尽管SAE的发病率和临床相关性很高，但其确切的发病机制尚不完全清楚，也没有具体的治疗策略可用。调节性T细胞(Tregs)在SAE的发病机制中起一定作用，被认为与减轻脓毒症引起的炎症和免疫反应、促进T辅助细胞(Th)2细胞功能转移、缓解神经炎症、改善血脑屏障(BBB)功能等有关。此外，从临床角度来看，这些细胞具有改善SAE患者神经和精神/精神症状的潜在价值。该综述旨在提供从最初的临床表现到长期的认知损害的SAE的概述，并总结其发病机制的主要特征。此外，对Tregs可能影响SAE发病机制的主要机制进行了详细的概述。最后，考虑到Tregs可能是SAE免疫调节干预的新靶点，讨论了不同的治疗方案，旨在促进Tregs的外周和脑内渗透。
Sepsis-associated encephalopathy (SAE) is a diffuse central nervous system (CNS) dysfunction during sepsis, and is associated with increased mortality and poor outcomes in septic patients. Despite the high incidence and clinical relevance, the exact mechanisms driving SAE pathogenesis are not yet fully understood, and no specific therapeutic strategies are available. Regulatory T cells (Tregs) have a role in SAE pathogenesis, thought to be related with alleviation of sepsis-induced hyper-inflammation and immune responses, promotion of T helper (Th) 2 cells functional shift, neuroinflammation resolution, improvement of the blood-brain barrier (BBB) function, among others. Moreover, in a clinical point of view, these cells have the potential value of improving neurological and psychiatric/mental symptoms in SAE patients. This review aims to provide a general overview of SAE from its initial clinical presentation to long-term cognitive impairment and summarizes the main features of its pathogenesis. Additionally, a detailed overview on the main mechanisms by which Tregs may impact SAE pathogenesis is given. Finally, and considering that Tregs may be a novel target for immunomodulatory intervention in SAE, different therapeutic options, aiming to boost peripheral and brain infiltration of Tregs, are discussed.
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影响因子：
13.6
作者：
Da Mesquita S;Herz J;Wall M;Dykstra T;de Lima KA;Norris GT;Dabhi N;Kennedy T;Baker W;Kipnis J
通讯作者：
Kipnis J
影响因子：
82.9
作者：
Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
通讯作者：
Anrather J
DOI：
10.1002/stem.3320
发表时间：
2021-03
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Caplan HW;Prabhakara KS;Toledano Furman NE;Zorofchian S;Kumar A;Martin C;Xue H;Olson SD;Cox CS Jr
通讯作者：
Cox CS Jr
影响因子：
3.7
作者：
Bonfante, Sandra;Joaquim, Larissa;Petronilho, Fabricia
通讯作者：
Petronilho, Fabricia
影响因子：
3.7
作者：
Safina I;Al Sudani ZAN;Hashoosh A;Darrigues E;Watanabe F;Biris AS;Dings RPM;Bao Vang K
通讯作者：
Bao Vang K