Association Between MitoScore, BMI, and Body Fat Percentage as a Predictive Marker for the Outcome of In-Vitro Fertilization (IVF).
Association Between MitoScore, BMI, and Body Fat Percentage as a Predictive Marker for the Outcome of In-Vitro Fertilization (IVF).
复制标题
MitoScore、BMI和体脂百分比作为体外受精（IVF）结局的预测标志物之间的相关性
DOI：
10.7759/cureus.27367
复制
发表时间：
2022-07
影响因子：
1.2
通讯作者：
Bustillo, Maria
中科院分区：
文献类型：
--
作者：
Arora, Himanshu;Collazo, Ineabelle;Eisermann, Juergen;Hendon, Nicholas;Kuchakulla, Manish;Khodamoradi, Kajal;Bidhan, Joginder;Dullea, Alexandra;Zucker, Isaac;Khosravizadeh, Zahra;Shah, Parth;Bustillo, Maria
不孕症的定义是在12个月内不能建立怀孕的定期和无保护的性交。针对这些问题，辅助生殖技术（ART）对不孕症的治疗管理产生了深远的影响。然而，体外受精（IVF）的成功率受到一些内部和外部因素的干扰，一种相对较新的胚胎评估方法被称为MitoScore（Igenomix，迈阿密，美国）。因此，我们试图评估MitoScore是否有助于预测IVF结局，并评估MitoScore、BMI和体脂百分比在决定ART成功率方面的关系。方法采用回顾性队列研究，对166名年龄在26-43岁之间接受ART的女性进行非整倍体植入前基因检测（PGT-A），以确定MitoScore，BMI和体脂百分比是否影响IVF结局。结果孕妇的MitoScore、BMI和体脂百分比均显著低于非孕妇。此外，MitoScore与IVF结局的亚类（分娩，生化妊娠和自然流产）相关，并与生化妊娠患者的BMI呈正相关。结论MitoScore、BMI和体脂百分比可作为ART成功与否的关键参数，但在此阶段，MitoScore、BMI和体脂百分比之间的相关性似乎不是决定妊娠结局的重要混杂因素。尽管如此，仍需要考虑许多因素才能可靠地建立相关性。
Background Infertility is defined as the inability to establish a pregnancy within 12 months of regular and unprotected sexual intercourse. In response to these problems, assisted reproductive techniques (ARTs) have made profound impacts on the therapeutic management of infertility. However, in-vitro fertilization (IVF) success rates are confounded by several internal and external factors. A relatively new approach to embryo assessment is known as MitoScore (Igenomix, Miami, USA). As a result, we sough to evaluate whether MitoScore can help in predicting in IVF outcomes, and to assess the relationship between MitoScore, BMI, and body fat percentage in determining the success of ARTs. Methods Using retrospective cohort, a study population consisting of 166 women aged 26-43 who were undergoing ART with pre-implantation genetic testing for aneuploidy (PGT-A) was assessed to determine if MitoScore, BMI, and body fat percentage impacted IVF outcomes. Results MitoScore, BMI, and body fat percentage were significantly lower in pregnant women as compared to non-pregnant women. Furthermore, MitoScore was correlated with subclasses of IVF outcomes (delivery, biochemical pregnancy, and spontaneous abortion) and was found to be positively correlated with BMI in patients with biochemical pregnancies. Conclusion Our findings suggest that MitoScore, BMI, and body fat percentage could act as critical parameters in determining the success of ART. However, the association between MitoScore, BMI, and body fat percentage does not appear to be a significant confounding factor to determine pregnancy outcome at this stage. Still, many factors need to be considered to establish the correlation reliably.
登录
查看更多内容
影响因子：
4.5
作者：
Fragouli E;Spath K;Alfarawati S;Kaper F;Craig A;Michel CE;Kokocinski F;Cohen J;Munne S;Wells D
通讯作者：
Wells D
影响因子：
6.7
作者：
Rubio, Carmen;Rodrigo, Lorena;Simon, Carlos
通讯作者：
Simon, Carlos
影响因子：
3.1
作者：
Kudesia, Rashmi;Wu, Hongyu;Beim, Piraye Yurttas
通讯作者：
Beim, Piraye Yurttas
影响因子：
2.9
作者：
Nemer, Laurice Bou;Shi, Haolin;Bukulmez, Orhan
通讯作者：
Bukulmez, Orhan
影响因子：
3.7
作者：
Boynukalin, Fazilet Kubra;Gultomruk, Meral;Bahceci, Mustafa
通讯作者：
Bahceci, Mustafa