Pathology of suspected acquired immune deficiency syndrome in children: a study of eight cases.
Pathology of suspected acquired immune deficiency syndrome in children: a study of eight cases.
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疑似儿童获得性免疫缺陷综合征的病理学：八例病例的研究。
DOI：
10.3109/15513818409041189
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
R. Rapkin
中科院分区：
文献类型：
--
作者：
V. Joshi;J. Oleske;A. Minnefor;R. Singh;T. Bokhari;R. Rapkin
对8例疑似获得性免疫缺陷综合征（AIDS）患儿的淋巴网状和其他器官活检和/或尸检材料进行了研究。这些儿童的父母一方或双方都有一种或多种已知的艾滋病危险因素，如静脉注射药物滥用、卖淫、海地血统。淋巴结的组织学表现如下：(1)滤泡增生伴正常细胞旁皮质；(2)滤泡增生伴旁皮质缺失；(3)滤泡萎缩伴旁皮质缺失。淋巴样间质性肺炎（LIP），一种以前未报道的艾滋病病变，出现在4例。提示肺淋巴样病变可能是累及B细胞的更广泛的淋巴样增生的一部分。8例中2例胸腺的大体和显微镜特征表明，这些儿童的免疫缺陷不是先天性的。当病理结果与疑似病例和肺部病变的临床和免疫学特征相关联时，可以帮助诊断该综合征。后者在决定肺部疾病过程的治疗类型时很重要。
Biopsy and/or autopsy material from lymphoreticular and other organs was studied in 8 children with suspected acquired immune deficiency syndrome (AIDS). One or both parents of each of these children had one or more of the recognized risk factors for AIDS, such as intravenous drug abuse, prostitution, Haitian origin. The following histologic patterns were noted in the lymph nodes: (1) follicular hyperplasia with normocellular paracortex, (2) follicular hyperplasia with depletion of paracortex, and (3) atrophy of follicles with depletion of paracortex. Lymphoid interstitial pneumonitis (LIP), a previously unreported lesion in AIDS, was present in 4 cases. It is suggested that the pulmonary lymphoid lesion may be part of a more generalized lymphoid hyperplasia involving B cells. The gross and microscopic features of the thymus, available in 2 of the 8 cases, indicated that the immunologic defect in these children was not of congenital type. Pathologic findings can be helpful in the diagnosis of the syndrome when correlated with clinical and immunologic features of suspected cases and of the pulmonary lesion. The latter is of importance in deciding the type of therapy to be given for the pulmonary disease process.
性乱和吸毒成瘾的母亲所生婴儿患有 T4/T8 比例逆转的获得性免疫缺陷。
DOI：
--
发表时间：
1983
期刊：
JAMA : the journal of the American Medical Association
影响因子：
--
作者：
Rubinstein,A;Sicklick,M;Gupta,A;Bernstein,L;Klein,N;Rubinstein,E;Spigland,I;Fruchter,L;Litman,N;Lee,H;Hollander,M
通讯作者：
Hollander,M
典型血友病患者细胞介导的免疫力受损。
DOI：
10.1056/nejm198301133080205
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lederman,MM;Ratnoff,OD;Scillian,JJ;Jones,PK;Schacter,B
通讯作者：
Schacter,B
患有获得性免疫缺陷综合症的男性女性性伴侣的免疫缺陷。
DOI：
10.1056/nejm198305193082001
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
--
作者：
Harris,C;Small,CB;Klein,RS;Friedland,GH;Moll,B;Emeson,EE;Spigland,I;Steigbigel,NH
通讯作者：
Steigbigel,NH