Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma.
Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma.
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DOI：
10.1002/cncr.23825
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发表时间：
2008-10-15
期刊：
影响因子：
6.2
通讯作者：
Lai, Stephen Y.
中科院分区：
文献类型：
--
作者：
Nance, Melonie A.;Seethala, Raja R.;Wang, Yun;Chiosea, Simion I.;Myers, Eugene N.;Johnson, Jonas T.;Lai, Stephen Y.
关键词：
粘液表皮样癌的组织学分级是一个确定的预后预测因子，并影响治疗方案。高级别MEC的肿瘤行为比低级别MEC更具侵袭性，导致更强化的治疗方案。中度MEC患者的结局不太清楚;因此，该组的最佳治疗方案尚未明确。研究了头颈部MEC患者的治疗方案和生存结局。回顾性临床审查和前瞻性审查的组织病理学分级进行了最新建立的分级系统的50例MEC的头部和颈部从1983年至2004年。随着组织学分级从低到中再到高，总生存期（P <0.0001）和无病生存期（P <0.001）显著降低。中度MEC患者的总体生存率和无病生存率明显优于高度疾病患者。低级别和中等级别MEC患者的总体生存率和无病生存率相似。中度MEC患者的疾病复发率较低，但这不会导致疾病死亡。虽然没有低级别或中等级别MEC患者死于疾病，但52%的高级别MEC患者死于疾病。多因素分析显示组织学分级、年龄和手术切缘状态显著预测预后。这些研究结果表明，在目前的组织病理学分类系统下，中级MEC的行为与低级MEC相当，而与高级MEC不同，从而可以建立基于证据的治疗方案。
Histopathologic grade of mucoepidermoid carcinoma (MEC) is an established predictor of prognosis and affects treatment protocol. Tumor behavior is more aggressive in high-grade than in low-grade MEC, leading to a more intensive treatment protocol. Outcomes for patients with intermediate-grade MEC are less clear; therefore, the optimal treatment protocol for this group is not well defined. The treatment protocol and survival outcomes of patients treated for MEC of the head and neck was investigated. A retrospective clinical review and prospective review of histopathologic grading were undertaken using the most recently established grading system of 50 patients with MEC of the head and neck from 1983 through 2004. As histologic grade increased from low to intermediate to high, overall survival (P <.0001) and disease-free survival (P <.001) were significantly decreased. Overall and disease-free survival were significantly better for patients with intermediate-grade MEC than those with high-grade disease. Overall and disease-free survival were similar for patients with low-grade and intermediate-grade MEC. There was a low rate of disease recurrence in patients with intermediate-grade MEC, but this did not lead to death from disease. Although no patients with low-grade or intermediate-grade MEC died of disease, 52% of patients with high-grade MEC died of disease. Multivariate analysis revealed that histologic grade, age, and surgical margin status significantly predicted prognosis. These findings suggest that, under the current histopathologic classification system, the behavior of intermediate-grade MEC is comparable to that of low-grade MEC and different from high-grade MEC, allowing for the establishment of an evidence-based treatment protocol.
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影响因子：
1.4
作者：
BATSAKIS, JG;LUNA, MA
通讯作者：
LUNA, MA
影响因子：
1.2
作者：
Etemad-Moghadam, Shahroo;Baghaee, Fereshteh;Eslami, Mohammad
通讯作者：
Eslami, Mohammad
DOI：
10.1002/hed.2880170203
发表时间：
1995-03-01
影响因子：
2.9
作者：
HICKS, MJ;ELNAGGAR, AK;BATSAKIS, JG
通讯作者：
BATSAKIS, JG
影响因子：
3.4
作者：
Lopes, MA;Perez, DED;Kowalski, LP
通讯作者：
Kowalski, LP
影响因子：
5.6
作者：
Brandwein, MS;Ivanov, K;Mills, SE
通讯作者：
Mills, SE