Morphological factors affecting vortex core instability on 4D flow MRI of unruptured cerebral aneurysms
Morphological factors affecting vortex core instability on 4D flow MRI of unruptured cerebral aneurysms
复制标题
影响未破裂脑动脉瘤4D流MRI涡核不稳定性的形态因素
DOI：
10.1080/01616412.2021.2004365
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发表时间：
2022
影响因子：
1.9
通讯作者：
Nakada Mitsutoshi
中科院分区：
文献类型：
--
作者：
Futami Kazuya;Misaki Kouichi;Uno Takehiro;Nambu Iku;Kamide Tomoya;Nakada Mitsutoshi
颅内动脉瘤破裂时，颅内动脉瘤内涡流的时空不稳定性可能与未破裂的脑动脉瘤破裂有关。我们确定了影响颅内动脉瘤内涡核模式的形态学因素，并根据四维（4D）流动磁共振成像（MRI）上的不稳定性进行分类，并确定了这些因素的截止值，以区分不稳定的核心patterns.MethodsWe将40例未破裂动脉瘤的涡核模式分为稳定，稳定与拍打尖端，连续变形波或线圈状，和非可视化。我们统计学比较了9个形态参数之间的动脉瘤组与个别patterns.ResultsThe涡核是稳定的（n= 16）（A组），稳定的扑翼提示（n= 15）（组B），波或线圈状（n= 7）（C组），和非可视化（n= 2）（D组）。由于A组和B组之间没有统计学显著差异，我们比较了A组和B组与其他组之间的差异。多因素Logistic回归分析发现，大小比（SR）是唯一的独立显著性参数（p< 0.05）。A、B组与C组之间以及A、B组与C、D组之间的受试者工作特征分析显示，SR的曲线下面积最大形态学因素中的（0.829 [95% CI，0.642-1.0]; 0.867 [95% CI，0.715-1.0]）; SR截止值为1.72（特异性0.714，敏感性0.756;特异性0.806，敏感性0.778）。结论根据4D flow MRI上的涡核模式，SR是导致涡核不稳定的独立形态学因素。计算流体动力学; 3D：三维; 4D：四维; MRI：磁共振成像; MRA：磁共振血管造影;伊卡：颈内动脉; AR：纵横比; SR：尺寸比; CI：置信区间; AUC：曲线下面积; ROC：受试者操作特征
ObjectiveThe spatiotemporal instability of intra-aneurysmal vortex flow may be associated with unruptured cerebral aneurysm rupture. We identified morphological factors that affect intra-aneurysmal vortex core patterns classified based on the instability on four-dimensional (4D) flow magnetic resonance imaging (MRI) and determined cutoff values for the factors to discriminate unstable core patterns.MethodsWe classified vortex core patterns of 40 unruptured aneurysms on 4D flow MRI into stable, stable with a flapping tip, continuously deforming wave-or-coil-like, and non-visualized. We statistically compared nine morphological parameters among aneurysm groups with individual patterns.ResultsThe vortex cores were stable (n= 16) (group A), stable with a flapping tip (n= 15) (group B), wave-or-coil-like (n= 7) (group C), and non-visualized (n= 2) (group D). Since there were no statistically significant differences between groups A and B, we compared the difference between the groups A and B and the other groups. Multivariate logistic regression analyses found that size ratio (SR) was an only independently significant parameter (p< 0.05). The receiver-operating characteristic analysis between groups A and B and group C and between groups A and B and groups C and D revealed that the area under the curve value for SR was the highest (0.829 [95% CI, 0.642–1.0]; 0.867 [95% CI, 0.715–1.0], respectively) among morphological factors; the cutoff value for SR was 1.72 (specificity 0.714, sensitivity 0.756; specificity 0.806, sensitivity 0.778, respectively).ConclusionSR was an independent morphological factor contributing to vortex core instability based on the vortex core patterns on 4D flow MRI.Abbreviations:CFD: computational fluid dynamics; 3D: three-dimensional; 4D: four-dimensional; MRI: magnetic resonance imaging; MRA: magnetic resonance angiography; ICA: internal carotid artery; AR: aspect ratio; SR: size ratio; CI: confidence interval; AUC: area under the curve; ROC: receiver-operating characteristic
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影响因子：
4.8
作者：
Lauric, Alexandra;Baharoglu, Merih I.;Malek, Adel M.
通讯作者：
Malek, Adel M.
DOI：
10.3174/ajnr.a3678
发表时间：
2014-02
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Byrne G;Mut F;Cebral J
通讯作者：
Cebral J
影响因子：
2.4
作者：
Xu, Lijian;Liang, Fuyou;Liu, Hao
通讯作者：
Liu, Hao
DOI：
10.1002/jmri.1880030213
发表时间：
1993-03-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
TANG, C;BLATTER, DD;PARKER, DL
通讯作者：
PARKER, DL
影响因子：
2.8
作者：
Meckel, Stephan;Stalder, Aurelien F.;Wetzel, Stephan G.
通讯作者：
Wetzel, Stephan G.