Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium.
Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium.
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DOI：
10.1038/ncomms12748
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发表时间：
2016-09-07
影响因子：
16.6
通讯作者：
Sad, Subash
中科院分区：
文献类型：
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作者：
Joseph, Julie;Ametepe, Emmanuelle S.;Haribabu, Naveen;Agbayani, Gerard;Krishnan, Lakshmi;Blais, Alexandre;Sad, Subash
毒性细胞内病原体，如沙门氏菌属，涉及许多毒力因子以破坏宿主防御机制，从而诱导慢性感染，导致伤寒或其他慢性炎性病症的恶化。在这里，我们显示了叉头转录因子FoxO3a在鼠伤寒沙门氏菌（ST）感染小鼠过程中的作用。虽然FoxO3a信号传导不影响CD 8 + T细胞对ST反应的发展，但FoxO3a通过限制氧化应激的持续性，具有重要的保护作用，特别是在感染的慢性阶段。此外，FoxO3a信号传导调节巨噬细胞中的ERK信号传导，这导致促炎状态的维持。FoxO3a信号传导不影响细胞增殖或细胞死亡。因此，这些结果揭示了FoxO3a在慢性毒性细胞内细菌感染期间促进宿主存活的机制。 FoxO3a信号对急性细菌感染的影响有限。在这里，作者表明，FoxO3a通过抑制氧化应激和ERK信号传导促进小鼠对慢性鼠伤寒沙门氏菌感染的存活。
Virulent intracellular pathogens, such as the Salmonella species, engage numerous virulence factors to subvert host defence mechanisms to induce a chronic infection that leads to typhoid or exacerbation of other chronic inflammatory conditions. Here we show the role of the forkhead transcription factor FoxO3a during infection of mice with Salmonella typhimurium (ST). Although FoxO3a signalling does not affect the development of CD8+ T cell responses to ST, FoxO3a has an important protective role, particularly during the chronic stage of infection, by limiting the persistence of oxidative stress. Furthermore, FoxO3a signalling regulates ERK signalling in macrophages, which results in the maintenance of a proinflammatory state. FoxO3a signalling does not affect cell proliferation or cell death. Thus, these results reveal mechanisms by which FoxO3a promotes host survival during infection with chronic, virulent intracellular bacteria. FoxO3a signalling has limited influence over acute bacterial infection. Here the authors show that FoxO3a promotes survival of mice in response to chronic Salmonella typhimurium infection by restraining oxidative stress and ERK signalling.
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影响因子：
8.7
作者：
Broz P;Monack DM
通讯作者：
Monack DM
影响因子：
15.9
作者：
Aikawa, R;Komuro, I;Yazaki, Y
通讯作者：
Yazaki, Y
影响因子：
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作者：
Fan, WuQiang;Morinaga, Hidetaka;Olefsky, Jerrold M.
通讯作者：
Olefsky, Jerrold M.
影响因子：
64.5
作者：
Arpaia N;Godec J;Lau L;Sivick KE;McLaughlin LM;Jones MB;Dracheva T;Peterson SN;Monack DM;Barton GM
通讯作者：
Barton GM
影响因子：
30.5
作者：
通讯作者：
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