Amyloid biomarkers as predictors of conversion from mild cognitive impairment to Alzheimer's dementia: a comparison of methods.
Amyloid biomarkers as predictors of conversion from mild cognitive impairment to Alzheimer's dementia: a comparison of methods.
复制标题
DOI：
10.1186/s13195-020-00721-3
复制
发表时间：
2020-11-19
期刊：
影响因子：
--
通讯作者：
Alzheimer Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Sörensen A;Blazhenets G;Schiller F;Meyer PT;Frings L;Alzheimer Disease Neuroimaging Initiative
淀粉样蛋白-β (Aβ) PET 是从轻度认知障碍 (MCI) 转变为阿尔茨海默氏痴呆 (AD) 的既定预测因子。我们比较了三种 PET（包括基于体素 Cox 回归的方法）和一种脑脊液 (CSF) 结果测量的预测能力。数据集是从 ADNI 数据库检索的。在训练数据集中（N = 159），使用体素Cox回归和主成分分析来识别转换相关区域（分别为Cox-VOI和AD转换相关模式（ADCRP））。在测试数据集（N = 129）中，通过Cox模型（针对年龄和性别进行校正）比较AD典型脑区（复合SUVR）或Cox-VOI中平均归一化18F-弗洛贝吡摄取（SUVR）的预测值以及ADCRP和CSF Aβ42/Aβ40的模式表达评分（PES）作为预测因子。所有四个 Aβ 测量值都是显着的预测因子 (p< 0.001)。预测准确度（Harrell’s c）显示出从 Cox-SUVR（c = 0.71；HR = 1.84 每 Z 分数增加）、复合 SUVR（c = 0.73；HR = 2.18）、CSF Aβ42/Aβ40（c = 0.75；HR = 0.75；HR = 2.18）逐步显着增加。 HR = 3.89）至PES（c = 0.77；HR = 2.71）。 ADCRP 的 PES 是最具预测性的 Aβ PET 结果指标，与 CSF Aβ42/Aβ40 相当，具有轻微但具有统计学意义的优势。
Amyloid-β (Aβ) PET is an established predictor of conversion from mild cognitive impairment (MCI) to Alzheimer’s dementia (AD). We compared three PET (including an approach based on voxel-wise Cox regression) and one cerebrospinal fluid (CSF) outcome measures in their predictive power. Datasets were retrieved from the ADNI database. In a training dataset (N = 159), voxel-wise Cox regression and principal component analyses were used to identify conversion-related regions (Cox-VOI and AD conversion-related pattern (ADCRP), respectively). In a test dataset (N = 129), the predictive value of mean normalized 18F-florbetapir uptake (SUVR) in AD-typical brain regions (composite SUVR) or the Cox-VOI and the pattern expression score (PES) of ADCRP and CSF Aβ42/Aβ40 as predictors were compared by Cox models (corrected for age and sex). All four Aβ measures were significant predictors (p < 0.001). Prediction accuracies (Harrell’s c) showed step-wise significant increases from Cox-SUVR (c = 0.71; HR = 1.84 per Z-score increase), composite SUVR (c = 0.73; HR = 2.18), CSF Aβ42/Aβ40 (c = 0.75; HR = 3.89) to PES (c = 0.77; HR = 2.71). The PES of ADCRP is the most predictive Aβ PET outcome measure, comparable to CSF Aβ42/Aβ40, with a slight but statistically significant advantage.
登录
查看更多内容
影响因子：
5.7
作者：
Spetsieris PG;Eidelberg D
通讯作者：
Eidelberg D
影响因子：
29
作者：
Schreiber, Stefanie;Landau, Susan M.;Jagust, William J.
通讯作者：
Jagust, William J.
DOI：
10.1093/brain/aww160
发表时间：
2016-09
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Leuzy A;Chiotis K;Hasselbalch SG;Rinne JO;de Mendonça A;Otto M;Lleó A;Castelo-Branco M;Santana I;Johansson J;Anderl-Straub S;von Arnim CA;Beer A;Blesa R;Fortea J;Herukka SK;Portelius E;Pannee J;Zetterberg H;Blennow K;Nordberg A
通讯作者：
Nordberg A
影响因子：
12.7
作者：
Jack CR Jr;Barrio JR;Kepe V
通讯作者：
Kepe V
影响因子：
1.2
作者：
Spetsieris, Phoebe;Ma, Yilong;Eidelberg, David
通讯作者：
Eidelberg, David