Cerebral amyloid PET imaging in Alzheimer's disease.
Cerebral amyloid PET imaging in Alzheimer's disease.
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DOI：
10.1007/s00401-013-1185-7
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发表时间：
2013-11
影响因子：
12.7
通讯作者：
Kepe V
中科院分区：
文献类型：
--
作者：
Jack CR Jr;Barrio JR;Kepe V
阿尔茨海默氏病（AD）是一种无法治愈的疾病，它的破坏性影响给医疗保健系统和整个社会带来了越来越大的负担。在这种不祥的背景下，淀粉样蛋白（Aβ）成像被许多人认为对早期AD诊断和有效治疗干预的潜在发展至关重要。淀粉样蛋白成像正电子发射断层扫描程序为AD患者活体大脑中淀粉样蛋白-A β神经聚集体沉积的准确绘图和量化提供了机会。本文分析了目前Aβ成像探针的感知价值及其临床应用，并基于淀粉样蛋白成像结果，提出了淀粉样蛋白沉积对AD生物学及其进展的影响的假设。它还分析了弥漫在淀粉样蛋白成像领域的挥之不去的问题，即成像结果与Aβ聚集体的已知神经病理学脑区域沉积之间的明显矛盾。因此，该综述还讨论了关于脑Aβ沉积是否真正可视化和测量这些淀粉样蛋白成像剂的文献证据，这将对理解生物AD级联反应和监测这些替代Aβ标记物的治疗干预具有重要意义。
The devastating effects of the still incurable Alzheimer's disease (AD) project an ever increasing shadow of burden on the health care system and society in general. In this ominous context, amyloid (Aβ) imaging is considered by many of utmost importance for progress towards earlier AD diagnosis and for potential development of effective therapeutic interventions. Amyloid imaging positron emission tomography procedures offer the opportunity for accurate mapping and quantification of amyloid-Aβ neuroaggregate deposition in the living brain of AD patients. This review analyzes the perceived value of current Aβ imaging probes and their clinical utilization and, based on amyloid imaging results, offers a hypothesis on the effects of amyloid deposition on the biology of AD and its progression. It also analyzes lingering questions permeating the field of amyloid imaging on the apparent contradictions between imaging results and known neuropathology brain regional deposition of Aβ aggregates. As a result, the review also discusses literature evidence as to whether brain Aβ deposition is truly visualized and measured with these amyloid imaging agents, which would have significant implications in the understanding of the biological AD cascade and in the monitoring of therapeutic interventions with these surrogate Aβ markers.
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影响因子：
82.9
作者：
Backskai, BJ;Kajdasz, ST;Hyman, BT
通讯作者：
Hyman, BT
影响因子：
4
作者：
Cupidi, Chiara;Capobianco, Raffaella;Giaccone, Giorgio
通讯作者：
Giaccone, Giorgio
影响因子：
3.7
作者：
Arnold, Steven E.;Hyman, Bradley T.;Van Hoesen, Gary W.
通讯作者：
Van Hoesen, Gary W.
影响因子：
3
作者：
Chetelat, Gael;Villemagne, Victor L.;Rowe, Christopher C.
通讯作者：
Rowe, Christopher C.
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.