Secondary Metabolites from Fungal Endophytes of Echinacea purpurea Suppress Cytokine Secretion by Macrophage-Type Cells
Secondary Metabolites from Fungal Endophytes of Echinacea purpurea Suppress Cytokine Secretion by Macrophage-Type Cells
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紫锥菊真菌内生菌的次生代谢物抑制巨噬细胞型细胞的细胞因子分泌
DOI：
10.1177/1934578x1601100827
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发表时间：
2016
影响因子：
1.8
通讯作者：
Nadja B. Cech
中科院分区：
文献类型：
--
作者：
A. Kaur;M. Oberhofer;Monika Juzumaite;H. Raja;Travis V. Gulledge;Diana Kao;S. Faeth;S. Laster;N. Oberlies;Nadja B. Cech
Botanical extracts of Echinacea purpurea have been widely used for the treatment of upper respiratory infections. We sought to chemically examine fungal endophytes inhabiting E. purpurea, and to identify compounds produced by these endophytes with in vitro cytokine-suppressive activity. Twelve isolates from surface sterilized seeds of E. purpurea were subjected to fractionation and major components were isolated. Sixteen secondary metabolites belonging to different structural classes were identified from these isolates based on NMR and mass spectrometry data. The compounds were tested for their influence on cytokine secretion by murine macrophage-type cells. Alternariol (1), O-prenylporriolide (4), porritoxin (10) β-zearalenol (13), and (S)-zearalenone (14) inhibited production of TNF-α from RAW 264.7 macrophages stimulated with LPS in the absence of any significant cytotoxicity. This is the first report of a cytokine-suppressive effect for 4. The results of this study are particularly interesting given that they show the presence of compounds with cytokine-suppressive activity in endophytes from a botanical used to treat inflammation. Future investigations into the role of fungal endophytes in the biological activity of E. purpurea dietary supplements may be warranted.
影响因子：
5.1
作者：
El-Elimat T;Figueroa M;Ehrmann BM;Cech NB;Pearce CJ;Oberlies NH
通讯作者：
Oberlies NH
影响因子：
5.1
作者：
Junio HA;Sy-Cordero AA;Ettefagh KA;Burns JT;Micko KT;Graf TN;Richter SJ;Cannon RE;Oberlies NH;Cech NB
通讯作者：
Cech NB
影响因子：
5.6
作者：
Pugh, Nirmal D.;Tamta, Hemlata;Pasco, David S.
通讯作者：
Pasco, David S.