MicroRNA miR-150 is involved in Vα14 invariant NKT cell development and function.
MicroRNA miR-150 is involved in Vα14 invariant NKT cell development and function.
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DOI：
10.4049/jimmunol.1103342
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发表时间：
2012-03-01
期刊：
影响因子：
--
通讯作者：
Mi QS
中科院分区：
文献类型：
--
作者：
Zheng Q;Zhou L;Mi QS
CD1d-restricted Vα14 invariant natural killer T (iNKT) cells play an important role in the regulation of diverse immune responses. MicroRNA mediated RNA interference is emerging as a crucial regulatory mechanism in the control of iNKT cells differentiation and function. Yet, roles of specific microRNAs in the development and function of iNKT cells remain to be further addressed. Here, we identified the gradually increased expression of miR-150 during the maturation of iNKT cells in thymus. Using miR-150 knockout (KO) mice, we found that miR-150 deletion resulted in an interruption of iNKT cell final maturation in both thymus and periphery. Upon activation, iNKT cells from miR-150KO mice showed significantly increased IFN-γ production compared to wild type (WT) iNKT cells. Bone marrow transferring experiments demonstrated the cell-intrinsic characteristics of iNKT cell maturation and functional defects in mice lacking miR-150. Furthermore, miR-150 target c-Myb was significantly up-regulated in miR-150KO iNKT cells, which potentially contribute to iNKT cell defects in miR-150KO mice. Our data define a specific role of miR-150 in the development and function of iNKT cells.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
10.5
作者：
Allen, RD;Bender, TP;Siu, G
通讯作者：
Siu, G
影响因子：
4.4
作者：
Fedeli, Maya;Napolitano, Anna;Casorati, Giulia
通讯作者：
Casorati, Giulia
DOI：
10.1084/jem.191.5.771
发表时间：
2000-03-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kennedy MK;Glaccum M;Brown SN;Butz EA;Viney JL;Embers M;Matsuki N;Charrier K;Sedger L;Willis CR;Brasel K;Morrissey PJ;Stocking K;Schuh JC;Joyce S;Peschon JJ
通讯作者：
Peschon JJ
影响因子：
4.4
作者：
Aktan, Idil;Chant, Alan;Boyson, Jonathan E.
通讯作者：
Boyson, Jonathan E.