Development of surgical confocal scanning microscope for intra-operative imaging of brain tumors using near infrared fluorescence: Technicalnote
Development of surgical confocal scanning microscope for intra-operative imaging of brain tumors using near infrared fluorescence: Technicalnote
复制标题
开发使用近红外荧光对脑肿瘤进行术中成像的手术共焦扫描显微镜：技术说明
作者：
K. Sakatani;M. Kashiwasake;H. Terada;H. Zuo
摘要我们研制了一种共焦激光扫描显微镜，用于脑肿瘤的近红外荧光术中成像。吲哚菁绿色（ICG）的近红外图像的质量进行了比较，与外科共聚焦扫描（SCS）显微镜和传统的电荷耦合器件（CCD）相机，我们比较了一个充满ICG，这是位于小鼠大脑的管的图像。与CCD相机相比，SCS显微镜可以获得更精确的ICG荧光穿过脑组织的图像。此外，由于消除了杂散光，SCS显微镜可以在相对明亮的房间中清晰地成像ICG荧光，而CCD相机需要高暗度才能获得ICC图像。本SCS显微镜可以提供有用的脑肿瘤术中成像，特别是检测延伸到正常脑组织中的残留肿瘤组织。[神经研究2000; 22：533-536]
Abstract We developed a confocal laser scanning microscope for intra-operative imaging of brain tumors using near infrared fluorescence. The quality of near infrared images of Indocyanine Green (ICG) was compared with the surgical confocal scanning (SCS) microscope and a conventional charge-coupled device (CCD) camera; we compared images of a tube filled with ICG, which was located in the mouse brain. Compared to the CCD camera, the SCS microscope could obtain a more precise image of ICG fluorescence through the brain tissue. In addition, the SCS microscope could image ICG fluorescence clearly in a relatively light room because of elimination of stray light, while the CCD camera required high darkness to obtain ICC images. The present SCS microscope can give useful intra-operative imaging of brain tumors, particularly detection of residual tumor tissues that extend into normal brain tissues. [Neurol Res 2000; 22: 533-536]
影响因子：
4.8
作者：
Haglund, MM;Berger, MS;Hochman, DW
通讯作者：
Hochman, DW