Mapping heterogenous anisotropic tissue mechanical properties with transverse isotropic nonlinear inversion MR elastography.
Mapping heterogenous anisotropic tissue mechanical properties with transverse isotropic nonlinear inversion MR elastography.
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DOI：
10.1016/j.media.2022.102432
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发表时间：
2022-05
影响因子：
10.9
通讯作者：
Paulsen, Keith
中科院分区：
文献类型：
--
作者：
McGarry, Matthew;Van Houten, Elijah;Sowinski, Damian;Jyoti, Dhrubo;Smith, Daniel R.;Caban-Rivera, Diego A.;McIlvain, Grace;Bayly, Philip;Johnson, Curtis L.;Weaver, John;Paulsen, Keith
脑组织的白色物质束由高度排列的有髓鞘纤维组成;白色物质在结构上是各向异性的，并且预期表现出各向异性的机械行为。可以使用磁共振弹性成像（MRE）对组织的体内机械特性进行成像。MRE可以检测和监测影响组织结构的自然和疾病过程;然而，大多数MRE反演算法假设局部均匀特性和/或各向同性行为，这可能导致白色物质区域中的伪影。一个异构的，基于模型的横观各向同性子带为基础的非线性反演（TI-NLI）的实施证明。TI-NLI使用标准MRE运动测量和从扩散张量成像（DTI）估计的纤维方向重建体内脑组织的剪切模量、阻尼比、剪切各向异性和拉伸各向异性的精确图。TI-NLI的准确性进行了研究，使用合成数据在控制和现实的设置：观察到良好的定量和空间精度和估计参数之间的串扰是最小的。10个重复的，在体内，从健康受试者获得的MRE扫描共注册，以证明该技术的可重复性。所有力学性质类型的MRE图像均显示解剖结构分辨率良好，双侧对称。重复性与各向同性MRE方法相似，并且完全在临床成功所需的限度内。TI-NLI磁共振成像是一种有前途的新技术，用于临床研究各向异性组织，如大脑和肌肉。
The white matter tracts of brain tissue consist of highly-aligned, myelinated fibers; white matter is structurally anisotropic and is expected to exhibit anisotropic mechanical behavior. In vivo mechanical properties of tissue can be imaged using magnetic resonance elastography (MRE). MRE can detect and monitor natural and disease processes that affect tissue structure; however, most MRE inversion algorithms assume locally homogenous properties and/or isotropic behavior, which can cause artifacts in white matter regions. A heterogeneous, model-based transverse isotropic implementation of a subzone-based nonlinear inversion (TI-NLI) is demonstrated. TI-NLI reconstructs accurate maps of the shear modulus, damping ratio, shear anisotropy, and tensile anisotropy of in vivo brain tissue using standard MRE motion measurements and fiber directions estimated from diffusion tensor imaging (DTI). TI-NLI accuracy was investigated with using synthetic data in both controlled and realistic settings: excellent quantitative and spatial accuracy was observed and cross-talk between estimated parameters was minimal. Ten repeated, in vivo, MRE scans acquired from a healthy subject were co-registered to demonstrate repeatability of the technique. Good resolution of anatomical structures and bilateral symmetry were evident in MRE images of all mechanical property types. Repeatability was similar to isotropic MRE methods and well within the limits required for clinical success. TI-NLI MRE is a promising new technique for clinical research into anisotropic tissues such as the brain and muscle.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
4.2
作者：
Hiscox LV;Johnson CL;McGarry MDJ;Perrins M;Littlejohn A;van Beek EJR;Roberts N;Starr JM
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Starr JM
影响因子：
5
作者：
ElSheikh, Mona;Arani, Arvin;Huston, John, III
通讯作者：
Huston, John, III
影响因子：
2.9
作者：
Green, M. A.;Geng, G.;Bilston, L. E.
通讯作者：
Bilston, L. E.
DOI：
10.1016/j.jmbbm.2016.03.005
发表时间：
2016-06-01
影响因子：
3.9
作者：
Anderson, Aaron T.;Van Houten, Elijah E. W.;Johnson, Curtis L.
通讯作者：
Johnson, Curtis L.