High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults.
High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults.
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DOI：
10.1016/j.neurobiolaging.2018.01.010
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发表时间：
2018-05
影响因子：
4.2
通讯作者：
Starr JM
中科院分区：
文献类型：
--
作者：
Hiscox LV;Johnson CL;McGarry MDJ;Perrins M;Littlejohn A;van Beek EJR;Roberts N;Starr JM
体积结构磁共振成像（MRI）通常用于确定衰老中神经元丢失的程度，表现为脑萎缩。然而，大脑表现出其他生物物理特性，如机械性能，这可以用磁共振弹性成像（MRE）量化。MRE是一种新兴的非侵入性成像技术，用于测量粘弹组织特性，已被证明是神经组织完整性的敏感指标，如剪切刚度μ和阻尼比ξ参数所描述。研究目的是评价年轻人（19-30岁，n = 12）和健康老年人（66-73岁，n = 12）之间的总体和区域MRE参数差异，并评估MRE测量是否提供了体积磁共振成像测量的附加值。我们研究了全球大脑和6个感兴趣的区域（ROI），包括杏仁核，海马，尾状核，苍白球，壳核和丘脑的粘弹性。在老年人中，我们发现除海马体外，所有ROI中的μ均减少，表明广泛的大脑软化;在控制ROI体积后，这种影响仍然显着。相比之下，大脑皮层的相对粘弹性行为在不同年龄组之间没有差异，这表明组织微观结构的组织得到了保护。这些数据支持使用MRE作为一种新的成像生物标志物，用于表征与年龄相关的神经组织差异，而不是单独通过体积成像捕获。
Volumetric structural magnetic resonance imaging (MRI) is commonly used to determine the extent of neuronal loss in aging, indicated by cerebral atrophy. The brain, however, exhibits other biophysical characteristics such as mechanical properties, which can be quantified with magnetic resonance elastography (MRE). MRE is an emerging noninvasive imaging technique for measuring viscoelastic tissue properties, proven to be sensitive metrics of neural tissue integrity, as described by shear stiffness, μ and damping ratio, ξ parameters. The study objective was to evaluate global and regional MRE parameter differences between young (19–30 years, n = 12) and healthy older adults (66–73 years, n = 12) and to assess whether MRE measures provide additive value over volumetric magnetic resonance imaging measurements. We investigated the viscoelasticity of the global cerebrum and 6 regions of interest (ROIs) including the amygdala, hippocampus, caudate, pallidum, putamen, and thalamus. In older adults, we found a decrease in μ in all ROIs, except for the hippocampus, indicating widespread brain softening; an effect that remained significant after controlling for ROI volume. In contrast, the relative viscous-to-elastic behavior of the brain ξ did not differ between age groups, suggesting a preservation of the organization of the tissue microstructure. These data support the use of MRE as a novel imaging biomarker for characterizing age-related differences to neural tissue not captured by volumetric imaging alone.
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影响因子：
3.7
作者：
Klein C;Hain EG;Braun J;Riek K;Mueller S;Steiner B;Sack I
通讯作者：
Sack I
影响因子：
4.2
作者：
Callaghan MF;Freund P;Draganski B;Anderson E;Cappelletti M;Chowdhury R;Diedrichsen J;Fitzgerald TH;Smittenaar P;Helms G;Lutti A;Weiskopf N
通讯作者：
Weiskopf N
影响因子：
3.3
作者：
Johnson, Curtis L.;Holtrop, Joseph L.;McGarry, Matthew D. J.;Weaver, John B.;Paulsen, Keith D.;Georgiadis, John G.;Sutton, Bradley P.
通讯作者：
Sutton, Bradley P.
影响因子：
3.5
作者：
McGarry MD;Van Houten EE;Perriñez PR;Pattison AJ;Weaver JB;Paulsen KD
通讯作者：
Paulsen KD
朝向大脑解剖结构的弹性图。
影响因子：
3.7
作者：
Guo J;Hirsch S;Fehlner A;Papazoglou S;Scheel M;Braun J;Sack I
通讯作者：
Sack I