Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation.
Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation.
复制标题
死者供肾移植后移植物功能延迟患者的预测因素和一年结果
DOI：
10.1186/s12882-020-02181-1
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发表时间：
2020-12-04
期刊：
影响因子：
2.3
通讯作者：
Peng L
中科院分区：
文献类型：
--
作者：
Chen R;Wang H;Song L;Hou J;Peng J;Dai H;Peng L
背景移植肾功能延迟恢复（DGF）与边缘供肾的使用密切相关，边缘供肾的使用是由于移植过程中和受者体内的缺陷所致。我们的目的是预测DGF的发生率，并评估其对移植物存活的影响。方法本回顾性研究于2018年1月1日至2019年12月31日在中南大学湘雅二医院进行。我们将在不同年份进行手术的受者分类为培训和验证队列，并使用培训队列的数据分析DGF的预测因素。然后构建诺模图预测DGF的可能性，根据这些predictors.ResultsThe DGF的发病率为16.92%。二元Logistic回归分析显示DGF的发生率与冷缺血时间（CIT）、热缺血时间（WIT）、终末血清肌酐（Scr）浓度、移植前透析持续时间、供体死亡的主要原因和LifePort的使用相关。列线图的内部准确度为83.12%。1年移植肾存活率分别为93.59%和99.74%（P< 0.05）。
BackgroundDelayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival.MethodsThis retrospective study on kidney transplantation was conducted from January 1, 2018, to December 31, 2019, at the Second Xiangya Hospital of Central South University. We classified recipients whose operations were performed in different years into training and validation cohorts and used data from the training cohort to analyze predictors of DGF. A nomogram was then constructed to predict the likelihood of DGF based on these predictors.ResultsThe incidence rate of DGF was 16.92%. Binary logistic regression analysis showed correlations between the incidence of DGF and cold ischemic time (CIT), warm ischemic time (WIT), terminal serum creatine (Scr) concentration, duration of pretransplant dialysis, primary cause of donor death, and usage of LifePort. The internal accuracy of the nomogram was 83.12%. One-year graft survival rates were 93.59 and 99.74%, respectively, for the groups with and without DGF (P< 0.05).ConclusionThe nomogram established in this study showed good accuracy in predicting DGF after deceased donor kidney transplantation; additionally, DGF decreased one-year graft survival.
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影响因子：
6.2
作者：
Huang, Jiefu;Wang, Haibo;Liu, Yongfeng
通讯作者：
Liu, Yongfeng
影响因子：
3.1
作者：
Jochmans, Ina;Darius, Tom;Pirenne, Jacques
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影响因子：
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影响因子：
8.8
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通讯作者：
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影响因子：
6.2
作者：
Parker WF;Thistlethwaite JR Jr;Ross LF
通讯作者：
Ross LF