Role of mtDNA haplogroups in the prevalence of knee osteoarthritis in a southern Chinese population.
Role of mtDNA haplogroups in the prevalence of knee osteoarthritis in a southern Chinese population.
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mtDNA 单倍群在中国南方人群膝骨关节炎患病率中的作用
DOI：
10.3390/ijms15022646
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发表时间：
2014-02-14
影响因子：
5.6
通讯作者：
Bai Y
中科院分区：
文献类型：
--
作者：
Fang H;Liu X;Shen L;Li F;Liu Y;Chi H;Miao H;Lu J;Bai Y
线粒体DNA（mtDNA）与多种人类退行性疾病有关。然而，mtDNA在骨关节炎（OA）中的作用鲜为人知。为了探讨mtDNA单倍型群是否与膝关节OA的患病率有关，我们对中国南方187例膝关节OA患者和420例地理位置匹配的对照进行了全面的病例对照研究。在疾病严重程度研究中，OA患者根据Kellgren/Lawrence量表从2到4进行分类，并通过调整年龄和性别来分析数据。我们发现，单倍群G（OR = 3.834; 95% CI 1.139，12.908; p = 0.03）和T16362 C（OR = 1.715; 95% CI 1.174，2.506; p = 0.005）患者显示出OA发生的风险增加。此外，携带单倍群G的患者膝关节OA的严重程度进展更高（OR = 10.870; 95% CI 1.307，90.909; p = 0.007）。另一方面，具有单倍群B/B4（OR = 0.503; 95% CI 0.283，0.893; p = 0.019）/（OR = 0.483; 95% CI 0.245，0.954; p = 0.036）的人对OA发生的易感性较低。有趣的是，我们发现OA患者也表现出mtDNA含量的普遍增加。我们的研究表明，线粒体DNA单倍型群在调节OA的发展中发挥作用。
Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee OA patients and 420 geographically matched controls in southern China. OA patients were classified on the Kellgren/Lawrence scale from two to four for the disease severity study and the data were analyzed by adjusting for age and sex. We found that patients with haplogroup G (OR = 3.834; 95% CI 1.139, 12.908; p = 0.03) and T16362C (OR = 1.715; 95% CI 1.174, 2.506; p = 0.005) exhibited an increased risk of OA occurrence. Furthermore, patients carrying haplogroup G had a higher severity progression of knee OA (OR = 10.870; 95% CI 1.307, 90.909; p = 0.007). On the other hand, people with haplogroup B/B4 (OR = 0.503; 95% CI 0.283, 0.893; p = 0.019)/(OR = 0.483; 95% CI 0.245, 0.954; p = 0.036) were less susceptible for OA occurrence. Interestingly, we found OA patients also exhibited a general increase in mtDNA content. Our study indicates that the mtDNA haplogroup plays a role in modulating OA development.
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影响因子：
64.5
作者：
Sharpley MS;Marciniak C;Eckel-Mahan K;McManus M;Crimi M;Waymire K;Lin CS;Masubuchi S;Friend N;Koike M;Chalkia D;MacGregor G;Sassone-Corsi P;Wallace DC
通讯作者：
Wallace DC
缓激肽 B2 受体多态性对中国人群骨关节炎易感性和严重程度的影响
影响因子：
--
作者：
Chen S;Zhou Y;Li J;Shan LQ;Fan QY
通讯作者：
Fan QY
影响因子：
4.5
作者：
Suissa S;Wang Z;Poole J;Wittkopp S;Feder J;Shutt TE;Wallace DC;Shadel GS;Mishmar D
通讯作者：
Mishmar D
线粒体DNA多态性的鉴定会改变线粒体基质pH和细胞内钙动力学。
影响因子：
4.5
作者：
Kazuno, An-a;Munakata, Kae;Nagai, Takeharu;Shimozono, Satoshi;Tanaka, Masashi;Yoneda, Makoto;Kato, Nobumasa;Miyawaki, Atsushi;Kato, Tadafumi
通讯作者：
Kato, Tadafumi
影响因子：
27.4
作者：
Hudson G;Panoutsopoulou K;Wilson I;Southam L;Rayner NW;Arden N;Birrell F;Carluke I;Carr A;Chapman K;Deloukas P;Doherty M;McCaskie A;Ollier WE;Ralston SH;Reed MR;Spector TD;Valdes AM;Wallis GA;Wilkinson JM;Zeggini E;Samuels DC;Loughlin J;Chinnery PF;arcOGEN Consortium
通讯作者：
arcOGEN Consortium