The effect of bradykinin B2 receptor polymorphisms on the susceptibility and severity of osteoarthritis in a Chinese cohort.
The effect of bradykinin B2 receptor polymorphisms on the susceptibility and severity of osteoarthritis in a Chinese cohort.
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缓激肽 B2 受体多态性对中国人群骨关节炎易感性和严重程度的影响
DOI：
10.1155/2012/597637
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发表时间：
2012
影响因子：
--
通讯作者：
Fan QY
中科院分区：
文献类型：
--
作者：
Chen S;Zhou Y;Li J;Shan LQ;Fan QY
背景B2-缓激肽受体（BDKRB 2）已被报道与骨关节炎（OA）的发生和发展有关，然而，BDKRB 2基因多态性在OA中的作用仍然未知。法共招募了245名原发性膝关节OA患者和264名健康志愿者。对BDKRB 2基因多态性，− 58 T/C和+9/−9 bp多态性进行基因分型。结果在OA和对照组中，+9/-9 bp多态性的基因型分布和等位基因频率存在显著差异。Logistic回归分析显示，与+9/+9基因型相比，携带-9/-9基因型的携带者患膝关节骨性关节炎的风险显著增加（校正OR = 2.356，P < 0.001）。携带-9等位基因的OR显著高于携带+9等位基因的OR（校正OR = 1.52，P < 0.001）。+9/-9 bp多态性也决定了OA的放射学严重程度。-9 bp的存在与较早的OA相关。-58 T/C多态性不影响OA的风险和严重程度。结论BDKRB 2基因+9/-9 bp多态性可作为OA易感性和严重程度的遗传标记。
Background. The B2-bradykinin receptor (BDKRB2) has been reported to associate with onset and development of Osteoarthritis (OA); however, the role of BDKRB2 genetic polymorphisms in OA remains unknown. Method. A total of 245 patients with primary knee OA and 264 healthy volunteer were recruited. BDKRB2 gene polymorphisms, −58T/C and +9/−9 bp polymorphisms, were genotyped. Results. The genotype distributions and allele frequencies of +9/−9 bp polymorphisms significantly differed between OA and control subjects. Logistic regression analysis showed carriers with −9/−9 genotype had a significantly increased risk for knee OA compared with the +9/+9 genotype (adjusted OR = 2.356, P < 0.001). The OR for −9 allele carriage was significantly higher than +9 allele carriage (adjusted OR = 1.52, P < 0.001). The +9/−9 bp polymorphisms also determined the OA radiographic severity. The presence of −9 bp was associated with severer OA. The −58T/C polymorphisms did not affect OA risk and severity. Conclusion. The +9/−9 bp polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA.
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影响因子：
0.9
作者：
Bouillet, L.;Boccon-Gibod, I.;Massot, C.
通讯作者：
Massot, C.
DOI：
10.1006/bbrc.1995.1800
发表时间：
1995-06-06
影响因子：
3.1
作者：
KAMMERER, S;BRAUN, A;ROSCHER, AA
通讯作者：
ROSCHER, AA
影响因子：
7.3
作者：
Bellucci, F.;Cucchi, P.;Maggi, C. A.
通讯作者：
Maggi, C. A.
骨关节炎的炎症。
影响因子：
5.1
作者：
Goldring MB;Otero M
通讯作者：
Otero M
DOI：
10.1016/j.berh.2010.11.001
发表时间：
2010-12-01
影响因子：
5.2
作者：
Busija, Lucy;Bridgett, Lisa;Fransen, Marlene
通讯作者：
Fransen, Marlene