Glomerular inflammation induces resistance to tubular injury in the rat. A novel form of acquired, heme oxygenase-dependent resistance to renal injury.
Glomerular inflammation induces resistance to tubular injury in the rat. A novel form of acquired, heme oxygenase-dependent resistance to renal injury.
复制标题
肾小球炎症诱导大鼠对肾小管损伤的抵抗力。
DOI：
10.1172/jci119020
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Nath,KA
中科院分区：
文献类型：
--
作者：
Vogt,BA;Shanley,TP;Croatt,A;Alam,J;Johnson,KJ;Nath,KA
相当多的注意力集中在一个令人惊讶的生物学现象，其中暴露于一种损伤的组织获得对另一种损伤的抗性。我们确定了一个新的例子，获得性耐药急性肾功能衰竭和机制，有助于这种阻力。在诱导甘油诱导的急性肾衰竭前24小时给予大鼠肾毒性血清，可减少该模型中发生的功能和结构损伤。由于血红素加氧酶，血红素降解的限速酶，保护血红素蛋白诱导的肾损伤，我们质疑是否诱导血红素加氧酶的肾毒血清提供的保护。肾毒血清处理后6 h，肾脏血红素氧合酶（HO-1）mRNA表达被诱导，肾小管被确定为血红素氧合酶蛋白表达的部位。血红素加氧酶的诱导伴随着铁蛋白的肾含量增加，但不诱导其他抗氧化酶。血红素氧合酶的抑制阻止了肾毒血清的保护作用。肾毒性血清不能预防缺血性急性肾衰竭，在该模型中血红素加氧酶不被诱导。因此，肾毒血清通过诱导肾小管中的血红素加氧酶来防止甘油诱导的急性肾衰竭。这项研究首次证明了对肾小球炎症引起的肾小管损伤的抵抗力，揭示了这种抵抗力的机制，并揭示了肾小球和肾小管之间发生的对话。
Considerable attention is directed to a surprising biologic phenomenon wherein tissues exposed to one insult acquire resistance to another. We identify a novel example of acquired resistance to acute renal failure and a mechanism that contributes to such resistance. Nephrotoxic serum, administered to rats 24 h before the induction of glycerol-induced acute renal failure, reduces functional and structural injury that occurs in this model. Since heme oxygenase, the rate-limiting enzyme in heme degradation, protects against heme protein-induced renal injury, we questioned whether induction of heme oxygenase underlies the protection afforded by nephrotoxic serum. Kidney heme oxygenase (HO-1) mRNA was induced 6 h after nephrotoxic serum and renal tubules were identified as the site of expression of heme oxygenase protein. Induction of heme oxygenase was accompanied by increased renal content of ferritin but not by induction of other antioxidant enzymes. Inhibition of heme oxygenase prevented the protection afforded by nephrotoxic serum. Nephrotoxic serum did not protect against ischemic acute renal failure, a model in which heme oxygenase is not induced. Thus, nephrotoxic serum protects against glycerol-induced acute renal failure by inducing heme oxygenase in tubules. This study provides the first demonstration of resistance to tubular injury acquired from glomerular inflammation, uncovers a mechanism for such resistance, and exposes the dialogue that occurs between glomeruli and tubules.
登录
查看更多内容
近端肾小管阻塞会引发细胞对缺氧损伤的抵抗。
影响因子：
19.6
作者：
R. Zager
通讯作者：
R. Zager
急性肾衰竭的临床病程
影响因子：
1.6
作者：
R. Swann;J. Merrill
通讯作者：
J. Merrill
庆大霉素肾毒性。
DOI：
--
发表时间：
1982
期刊：
Journal of Laboratory and Clinical Medicine
影响因子：
--
作者：
W. Elliott;D. Houghton;David N. Gilbert;J. Baines;William M. Bennett
通讯作者：
William M. Bennett
内毒素在保护成年大鼠免受氧诱导的肺毒性中的作用。
影响因子：
15.9
作者：
L. Frank;J. Yam;R. Roberts
通讯作者：
R. Roberts
影响因子：
19.6
作者：
AGARWAL, A;BALLA, J;NATH, KA
通讯作者：
NATH, KA