T cell transgressions: Tales of T cell form and function in diverse disease states.
T cell transgressions: Tales of T cell form and function in diverse disease states.
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DOI：
10.1080/08830185.2021.1921764
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发表时间：
2022
影响因子：
5
通讯作者：
Watkins LR
中科院分区：
文献类型：
--
作者：
Harris KM;Clements MA;Kwilasz AJ;Watkins LR
对T细胞形态、功能和功能障碍的认识正在迅速发展。T细胞具有多种不同的效应功能，包括保护宿主免受感染，激活先天免疫系统细胞，释放细胞因子和趋化因子，并在免疫记忆中发挥重要作用。在健康的条件下，T细胞对入侵的病原体进行精心调整的攻击，同时将对宿主的损害降到最低。T细胞的阴暗面是它们也表现出自身反应性，对宿主细胞造成伤害，产生自身免疫。T细胞自身反应的机制是复杂和动态的。新兴研究正在阐明导致T细胞产生自身反应的机制，以及这种反应如何导致或促成周围和中枢神经系统内的各种疾病状态。本文综述了有关T细胞发育、分化和功能的基本信息。关键T细胞亚型，细胞因子创造他们的效应作用，和性别差异突出。病理性T细胞对各种外周和中枢疾病状态的贡献，由反应性错误引起，被强调，重点是多发性硬化症，类风湿性关节炎，骨关节炎，神经性疼痛和1型糖尿病。
Insights into T cell form, function, and dysfunction are rapidly evolving. T cells have remarkably varied effector functions including protecting the host from infection, activating cells of the innate immune system, releasing cytokines and chemokines, and heavily contributing to immunological memory. Under healthy conditions, T cells orchestrate a finely tuned attack on invading pathogens while minimizing damage to the host. The dark side of T cells is that they also exhibit autoreactivity and inflict harm to host cells, creating autoimmunity. The mechanisms of T cell autoreactivity are complex and dynamic. Emerging research is elucidating the mechanisms leading T cells to become autoreactive and how such responses cause or contribute to diverse disease states, both peripherally and within the central nervous system. This review provides foundational information on T cell development, differentiation, and functions. Key T cell subtypes, cytokines that create their effector roles, and sex differences are highlighted. Pathological T cell contributions to diverse peripheral and central disease states, arising from errors in reactivity, are highlighted, with a focus on multiple sclerosis, rheumatoid arthritis, osteoarthritis, neuropathic pain, and type 1 diabetes.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
5.1
作者：
Billi AC;Kahlenberg JM;Gudjonsson JE
通讯作者：
Gudjonsson JE
影响因子：
7.2
作者：
Balagopalan, Lakshmi;Coussens, Nathan P.;Sommers, Connie L.
通讯作者：
Sommers, Connie L.
白介素10在抑制肠炎的调节T细胞功能中的重要作用。
影响因子：
15.3
作者：
Asseman, C;Mauze, S;Leach, M W;Coffman, R L;Powrie, F
通讯作者：
Powrie, F