Comparison of cardiac output monitoring methods for detecting central hypovolemia due to lower body negative pressure.
Comparison of cardiac output monitoring methods for detecting central hypovolemia due to lower body negative pressure.
复制标题
用于检测由于下半身负压导致的中枢血容量不足的心输出量监测方法的比较。
DOI：
10.1109/iembs.2007.4352450
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Mukkamala,R
中科院分区：
文献类型：
--
作者：
Reisner,AT;Xu,D;Ryan,KL;Convertino,VA;Mukkamala,R
平均动脉压（MAP）的降低是进行性循环病理学的晚期指标。非侵入性监测方法是循环系统受损的上级指标，具有临床价值。经IRB批准，21名健康志愿者接受渐进性下体负压（LBNP）治疗，直至晕厥前症状发作。我们评估了进行性血容量不足期间动脉血压波形分析的四种研究方法的有用性：平均动脉压（MAP）; ModelFlow心输出量算法（MF）;长时间间期法（LTI）;以及脉压和心率乘积（PP*HR）。心输出量（EBI）的生物电阻抗测量提供了参考。当对结果进行分析时，我们发现方法之间存在显著差异。MF、LTI和EBI均与LBNP严重程度相对应，而MAP和PP*HR则与LBNP严重程度无关。在区分（a）减压至-45 mmHg;与（B）LBNP停止后5分钟恢复方面，MF和LTI之间存在显著差异：MF的受试者工作特征曲线下面积（ROC AUC）为0.57，LTI为0.76。在区分（a）耐受该方案的11名受试者（即，耐受更高水平的LBNP）;与（B）10名非耐受受试者相比，MF和LTI之间也存在显著差异：MF的ROC AUC为0.40，LTI为0.66。然而，MF和EBI之间没有显着差异。
Reduction in mean arterial pressure (MAP) is a late indictor of progressive circulatory pathology. Non-invasive monitoring methods that are superior indicators of circulatory compromise would be clinically valuable. With IRB approval, 21 healthy volunteers were subjected to progressive lower body negative pressure (LBNP) until the onset of presyncopal symptoms. We evaluated the usefulness of four investigational methods of arterial blood pressure waveform analysis during progressive hypovolemia: mean arterial pressure (MAP); the ModelFlow cardiac output algorithm (MF); the long time interval method (LTI); and the product of pulse pressure and heart rate (PP*HR). Electrical bioimpedance measurement of cardiac output (EBI) provided a reference. When results were analyzed, we found significant differences between the methods. MF, LTI, and EBI all corresponded with LBNP severity, while MAP and PP*HR did not. In terms of discriminating between (a) decompression to -45 mmHg; versus (b) recovery five minutes after LBNP cessation, there was a significant difference between MF and LTI: the receiver operating characteristic area-under-the-curve (ROC AUC) for MF was 0.57 and for LTI was 0.76. In terms of discriminating between (a) the 11 subjects who tolerated the protocol (i.e., tolerated higher levels of LBNP); versus (b) the 10 non-tolerant subjects, there was also a significant difference between MF and LTI: the ROC AUC for MF was 0.40 and for LTI was 0.66. There were no significant differences between MF nor EBI, however.
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使用假设的化学反应进行曲线解析
DOI：
--
发表时间：
1974
期刊：
影响因子：
--
作者：
E. A. Sylvestre;W. H. Lawton;M. Maggio
通讯作者：
M. Maggio
来自 Soret 激发拉曼光谱的细胞色素氧化酶中细胞色素 α 和 α 3 的协调几何结构和振动特性。
影响因子：
2.9
作者：
Babcock,GT;Callahan,PM;Ondrias,MR;Salmeen,I
通讯作者：
Salmeen,I
可通过 EPR 光谱检测细胞色素 C 氧化酶的成分。
DOI：
10.1016/0005-2728(74)90178-9
发表时间：
1974
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
C. Hartzell;Helmut Beinert
通讯作者：
Helmut Beinert
细胞色素氧化酶 II 中血红素的电子状态。
DOI：
10.1016/s0021-9258(17)38088-2
发表时间：
1978
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
G. Babcock;L. Vickery;G. Palmer
通讯作者：
G. Palmer
化合物 C 和细胞色素氧化酶相关衍生物的光谱表征。
DOI：
10.1073/pnas.78.3.1652
发表时间：
1981
影响因子：
11.1
作者：
Carter,KR;Antalis,TM;Palmer,G;Ferris,NS;Woodruff,WH
通讯作者：
Woodruff,WH