Construction and Evaluation of a Prototype High Resolution, Silicon Photomultiplier-Based, Tandem Positron Emission Tomography System.
Construction and Evaluation of a Prototype High Resolution, Silicon Photomultiplier-Based, Tandem Positron Emission Tomography System.
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DOI：
10.1109/tns.2013.2237788
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发表时间：
2013-02
影响因子：
1.8
通讯作者：
Raylman RR
中科院分区：
文献类型：
--
作者：
Stolin AV;Majewski S;Jaliparthi G;Raylman RR
虽然目前大多数市售PET扫描仪的性能足以满足许多标准临床应用，但某些特定任务可能需要专门的成像系统。这个项目的目标是探索一个小型的，高分辨率的原型系统，用于获得PET图像的能力和局限性。扫描仪由一系列探测器组成。一种是由0.7 × 0.7 × 3 mm ~ 3（间距0.8 mm）LYSO元件组成的20 × 20阵列的小型探测器。闪烁体阵列耦合到硅光电倍增管阵列。第二个探测器是一个96 × 72阵列的2 × 2 × 15 mm 3（间距= 2.1 mm）LYSO元件耦合到PSPMT。两个设备之间的间隔为180 mm。检测器的操作彼此一致。使用有限角度、最大似然期望最大化（MLEM）算法进行图像重建。该设备的评估包括测量空间分辨率和检测灵敏度作为距离的函数。该系统的轴向径向和切向空间分辨率范围为0.6 mm至0.9 mm FWHM;轴向分辨率范围为2.7 mm至4.6 mm FWHM。检测灵敏度为0.05 ~ 0.28%。空间分辨率和视场随着与小型探测器的距离而变化。串联探测器插件允许区分迷你热棒体模中的最小（1 mm直径）棒。结果表明，串联PET成像方案可以潜在地用于需要小区域上的高分辨率图像的应用中。
While the performance of most current commercially available PET scanners is sufficient for many standard clinical applications, some specific tasks likely require specialized imaging systems. The goal of this project is to explore the capabilities and limitations of a small, high-resolution prototype system for obtaining PET images. The scanner consists of a tandem of detectors. One is a small detector consisting of a 20 × 20 array of 0.7 × 0.7 × 3 mm3 (pitch 0.8 mm) LYSO elements. The scintillator array is coupled to an array of silicon photomultipliers. The second detector is a 96 × 72 array of 2 × 2 × 15 mm3 (pitch = 2.1 mm) LYSO elements coupled to PSPMTs. Separation between the two devices is 180 mm. The detectors are operated in coincidence with each other. Image reconstruction is performed using a limited angle, Maximum Likelihood Expectation Maximization (MLEM) algorithm. Evaluation of the device included measurements of spatial resolution and detection sensitivity as a function of distance. The transaxial radial and tangential spatial resolution of the system ranged from 0.6 mm to 0.9 mm FWHM; axial resolution ranged from 2.7 mm to 4.6 mm FWHM. Detection sensitivity ranged from 0.05 to 0.28%. Spatial resolution and field-of-view vary as a function of distance from the small detector. The tandem detector insert permitted differentiation of the smallest (1 mm diameter) rods in a mini-hot rod phantom. The results indicate that a tandem PET imaging scheme can be potentially employed in applications where high-resolution images over a small region are required.
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影响因子：
3.5
作者：
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DOI：
10.1016/j.nima.2010.10.089
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