The Meningeal Lymphatic System: A New Player in Neurophysiology.
The Meningeal Lymphatic System: A New Player in Neurophysiology.
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脑膜淋巴系统：神经生理学的新玩家。
DOI：
10.1016/j.neuron.2018.09.022
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发表时间：
2018-10-24
期刊：
影响因子：
16.2
通讯作者：
Kipnis J
中科院分区：
文献类型：
--
作者：
Da Mesquita S;Fu Z;Kipnis J
脑实质内流体动力学的特性是当前深入研究的一个焦点。尤其值得关注的是，它与脑部蛋白质积累和聚集相关疾病（如阿尔茨海默病，AD）存在关联。中枢神经系统的脑膜淋巴管最近被确认为在脑脊液（CSF）和组织间液（ISF）之间可溶性物质的复杂循环与交换过程中发挥着重要作用。例如，在衰老的哺乳动物中，脑膜淋巴管功能受损会导致有毒的β-淀粉样蛋白在脑实质中加速积累，进而加重与阿尔茨海默病相关的病理变化。鉴于脑膜淋巴管在功能上与脑脊液/组织间液沿血管周围的流入/流出相关联，并且最近有研究发现某些传统上被视为免疫分子的细胞因子具有神经调节作用，因此有理由推测，脑膜淋巴管的活性可能会改变脑脊液携带的免疫神经调节剂进入脑实质的难易程度，从而改变它们对大脑的影响。因此，在这篇展望文章中，我们探讨将脑膜淋巴系统视为神经生理学中一个新角色的观点。
在本文中，达·梅斯基塔等人阐述了脑膜淋巴系统的重要特征、它与大脑中其他大分子清除途径的相互作用，以及它在调节中枢神经系统免疫反应、细胞因子信号传导、神经细胞功能和行为方面的作用。
The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of particular relevance is its participation in diseases associated with protein accumulation and aggregation in the brain, such as Alzheimer’s disease (AD). The meningeal lymphatic vessels of the central nervous system have recently been recognized as an important player in the complex circulation and exchange of soluble contents between the cerebrospinal fluid (CSF) and the interstitial fluid (ISF). In aging mammals, for example, impaired functioning of the meningeal lymphatic vessels can lead to accelerated accumulation of toxic amyloid beta protein in the brain parenchyma, thus aggravating AD-related pathology. Given that meningeal lymphatic vessels are functionally linked to paravascular influx/efflux of the CSF/ISF, and in light of recent findings that certain cytokines, classically perceived as immune molecules, exert neuromodulatory effects, it is reasonable to suggest that the activity of meningeal lymphatics could alter the accessibility of CSF-borne immune neuromodulators to the brain parenchyma, thereby altering their effects on the brain. Accordingly, in this Perspective we discuss the suggestion that the meningeal lymphatic system can be viewed as a novel player in neurophysiology. In this article, Da Mesquita et al. describe important features of the meningeal lymphatic system, its interaction with other pathways of macromolecule clearance in the brain and its role in the regulation of CNS immune response, cytokine signaling, neural cell function and behavior.
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影响因子：
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作者：
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DOI：
10.1126/science.1252945
发表时间：
2014-10-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
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