Chemical Modifications in the Life of an mRNA Transcript.
Chemical Modifications in the Life of an mRNA Transcript.
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DOI：
10.1146/annurev-genet-120417-031522
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发表时间：
2018-11-23
影响因子：
11.1
通讯作者：
He C
中科院分区：
文献类型：
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作者：
Nachtergaele S;He C
过去八年来对信使RNA （mRNA）化学修饰的研究揭示了真核生物转录后基因调控的新水平。我们对这些修饰，特别是n6 -甲基腺苷（m6A）的理解取得了快速进展，揭示了它们在mRNA转录物整个生命周期中的作用。m6A甲基化提供了协调转录组加工和转换的快速机制，这在胚胎发育和细胞分化中很重要。为了响应细胞信号，m6A还可以调节特定转录本的翻译。这些机制可以在人类疾病中被劫持，包括许多癌症和病毒感染。除了m6A，许多其他mRNA修饰已经在转录组中被定位，但对它们的生物学功能知之甚少。随着方法的不断发展，我们将能够更广泛、更深入地研究这些修饰，这可能会揭示出丰富的新RNA生物学。
Investigations over the past eight years of chemical modifications on messenger RNA (mRNA) have revealed a new level of posttranscriptional gene regulation in eukaryotes. Rapid progress in our understanding of these modifications, particularly, N6-methyladenosine (m6A), has revealed their roles throughout the life cycle of an mRNA transcript. m6A methylation provides a rapid mechanism for coordinated transcriptome processing and turnover that is important in embryonic development and cell differentiation. In response to cellular signals, m6A can also regulate the translation of specific pools of transcripts. These mechanisms can be hijacked in human diseases, including numerous cancers and viral infection. Beyond m6A, many other mRNA modifications have been mapped in the transcriptome, but much less is known about their biological functions. As methods continue to be developed, we will be able to study these modifications both more broadly and in greater depth, which will likely reveal a wealth of new RNA biology.
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影响因子：
12.3
作者：
Amort T;Rieder D;Wille A;Khokhlova-Cubberley D;Riml C;Trixl L;Jia XY;Micura R;Lusser A
通讯作者：
Lusser A
影响因子：
16
作者：
Begley, Ulrike;Dyavaiah, Madhu;Begley, Thomas J.
通讯作者：
Begley, Thomas J.
影响因子：
56.9
作者：
DARNELL, JE;PHILIPSON, L;ADESNIK, M
通讯作者：
ADESNIK, M
影响因子：
23.9
作者：
Batista, Pedro J.;Molinie, Benoit;Wang, Jinkai;Qu, Kun;Zhang, Jiajing;Li, Lingjie;Bouley, Donna M.;Lujan, Ernesto;Haddad, Bahareh;Daneshvar, Kaveh;Carter, Ava C.;Flynn, Ryan A.;Zhou, Chan;Lim, Kok-Seong;Dedon, Peter;Wernig, Marius;Mullen, Alan C.;Xing, Yi;Giallourakis, Cosmas C.;Chang, Howard Y.
通讯作者：
Chang, Howard Y.
病毒mRNA帽的2'-O甲基化通过IFIT家族成员逃避了宿主的限制。
影响因子：
64.8
作者：
通讯作者：
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