Disruption of androgen receptor signaling in males by environmental chemicals.
Disruption of androgen receptor signaling in males by environmental chemicals.
复制标题
DOI：
10.1016/j.jsbmb.2011.04.004
复制
发表时间：
2011-10
影响因子：
4.1
通讯作者：
Prins, Gail S.
中科院分区：
文献类型：
--
作者：
Luccio-Camelo, Doug C.;Prins, Gail S.
雄激素干扰物是干扰内源性雄激素的生物合成、代谢或作用的环境化学物质，导致偏离正常的雄性发育编程和生殖道生长和功能。由于男性的性分化完全依赖于雄激素，因此对雄激素干扰物非常敏感。动物模型和流行病学证据将暴露于雄激素干扰化学品与精子数量减少、不孕症增加、睾丸发育不全综合征以及睾丸癌和前列腺癌联系起来。此外，在雄性分化处于高峰期的关键发育窗口期间，似乎对这些药剂的敏感性增加。各种体外和计算机模拟方法已被用于鉴定大类雄激素干扰分子，包括有机氯农药、工业化学品和具有雄激素受体配体能力的增塑剂。这些合成分子中的绝大多数作为抗雄激素。本次审查将突出雄激素干扰的化学物质，通过干扰雄激素受体的证据，讨论具体的化合物，有记录的男性生殖道扰动的体内证据。
Androgen-disruptors are environmental chemicals in that interfere with the biosynthesis, metabolism or action of endogenous androgens resulting in a deflection from normal male developmental programming and reproductive tract growth and function. Since male sexual differentiation is entirely androgen-dependent, it is highly susceptible to androgen-disruptors. Animal models and epidemiological evidence link exposure to androgen disrupting chemicals with reduced sperm counts, increased infertility, testicular dysgenesis syndrome, and testicular and prostate cancers. Further, there appears to be increased sensitivity to these agents during critical developmental windows when male differentiation is at its peak. A variety of in vitro and in silico approaches have been used to identify broad classes of androgen disrupting molecules that include organochlorinated pesticides, industrial chemicals, and plasticizers with capacity to ligand the androgen receptor. The vast majority of these synthetic molecules act as anti-androgens. This review will highlight the evidence for androgen disrupting chemicals that act through interference with the androgen receptor, discussing specific compounds for which there is documented in vivo evidence for male reproductive tract perturbations.
登录
查看更多内容
影响因子：
4.2
作者：
Bauer, ERS;Meyer, HHD;Sauerwein, H
通讯作者：
Sauerwein, H
影响因子：
10.4
作者：
Bhatia R;Shiau R;Petreas M;Weintraub JM;Farhang L;Eskenazi B
通讯作者：
Eskenazi B
影响因子：
3.8
作者：
COOK, JC;MULLIN, LS;BIEGEL, LB
通讯作者：
BIEGEL, LB
DOI：
10.1016/j.biocel.2009.11.013
发表时间：
2010-06-01
影响因子：
4
作者：
Bennett, Nigel C.;Gardiner, Robert A.;Gobe, Glenda C.
通讯作者：
Gobe, Glenda C.
影响因子：
4.8
作者：
Atanassova, N;McKinnell, C;Sharpe, RM
通讯作者：
Sharpe, RM