Organochlorine pesticides and male genital anomalies in the child health and development studies.
Organochlorine pesticides and male genital anomalies in the child health and development studies.
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DOI：
10.1289/ehp.7382
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发表时间：
2005-02
影响因子：
10.4
通讯作者：
Eskenazi B
中科院分区：
文献类型：
--
作者：
Bhatia R;Shiau R;Petreas M;Weintraub JM;Farhang L;Eskenazi B
隐睾和尿道下裂在人群中的发病率增加可能是由外源性环境因素引起的。我们在儿童健康与发育研究中进行了一项关于p，p′-二氯二苯基三氯乙烷（DDT）及其主要代谢物p，p′-二氯二苯基二氯乙烯（DDE）血清水平与隐睾和尿道下裂的病例对照研究，该研究是一项发生在1959年至1967年（DDT在美国生产和使用的时期）的纵向妊娠队列研究。血清可从75名出生时患有隐睾症，66名患有尿道下裂，4名同时患有两种疾病的男性儿童的母亲那里获得。我们随机选择了283名对照组，这些对照组的男性婴儿出生时没有这些条件。总的来说，我们没有观察到统计学显著的关系或趋势之间的结果和血清指标。校正母亲种族、甘油三酯水平和胆固醇水平后，与母亲血清DDE水平< 27.0 ng/mL的男孩相比，母亲血清DDE水平≥61.0 ng/mL的男孩隐睾和尿道下裂的比值比分别为1.34 [95%置信区间（CI），0.51-3.48]和1.18（95% CI，0.46-3.02）。对于DDT，与母亲血清DDT水平< 10.0 ng/mL的男孩相比，母亲血清DDT水平≥20.0 ng/mL的男孩的隐睾和尿道下裂的校正比值比分别为1.01（95%CI，0.44-2.28）和0.79（95%CI，0.33-1.89）。本研究不支持DDT或DDE与尿道下裂或隐睾症之间的相关性。
Increasing rates of cryptorchidism and hypospadias in human populations may be caused by exogenous environmental agents. We conducted a case–control study of serum levels of p,p′-dichlorodiphenyltrichloroethane (DDT) and its major metabolite, p,p′-dichlorodiphenyldichloroethylene (DDE), and cryptorchidism and hypospadias in the Child Health and Development Study, a longitudinal cohort of pregnancies that occurred between 1959 and 1967, a period when DDT was produced and used in the United States. Serum was available from the mothers of 75 male children born with cryptorchidism, 66 with hypospadias, and 4 with both conditions. We randomly selected 283 controls from the cohort of women whose male babies were born without either of these conditions. Overall, we observed no statistically significant relationships or trends between outcomes and serum measures. After adjusting for maternal race, triglyceride level, and cholesterol level, compared with boys whose mothers had serum DDE levels < 27.0 ng/mL, boys whose mothers had serum DDE levels ≥61.0 ng/mL had odds ratios of 1.34 [95% confidence interval (CI), 0.51–3.48] for cryptorchidism and 1.18 (95% CI, 0.46–3.02) for hypospadias. For DDT, compared with boys whose mothers had serum DDT levels < 10.0 ng/mL, boys whose mothers had serum DDT levels ≥20.0 ng/mL had adjusted odds ratios of 1.01 (95% CI, 0.44–2.28) for cryptorchidism and 0.79 (95% CI, 0.33–1.89) for hypospadias. This study does not support an association of DDT or DDE and hypospadias or cryptorchidism.
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