Respiratory cycle-related EEG changes during sleep reflect esophageal pressures.

Respiratory cycle-related EEG changes during sleep reflect esophageal pressures.
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睡眠期间与呼吸周期相关的脑电图变化反映了食管压力。

DOI:
10.1093/sleep/31.12.1713
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发表时间:
2008
期刊:
影响因子:
5.6
通讯作者:
Burns,JosephW
Burns,JosephW
中科院分区:
医学2区
文献类型:
--
作者:
Chervin,RonaldD;Malhotra,RamanK;Burns,JosephW

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研究目的通过数字分析证实了睡眠期间呼吸周期相关的脑电图变化(RCREC),并假设其代表微妙的吸气微觉醒,这可能有助于解释睡眠呼吸障碍患者的日间嗜睡。因此,我们首次研究了RCREC和食管压力波动(ΔPes)之间的关系。设计回顾性分析设置学术睡眠实验室患者40名成年人涉嫌睡眠呼吸障碍干预多导睡眠图与食管压力监测和自动计算ΔPes使用一种新的算法结果计算Δ Pes几乎所有呼吸周期在睡眠期间与视觉评分的选择呼吸周期样本(Spearmanrho= 0.86,P < 0.0001)。在sigma EEG范围(12.5-15.5 Hz)内的RCREC与ΔPes之间的负相关性最高,而在其他频率范围内的RCREC与ΔPes之间的负相关性最低。相比之下,在受试者之间的比较,β(15.5-30.5赫兹),并在较小程度上θ(4.5-7.5赫兹)RCREC,而不是西格玛RCREC,表现出显着的负相关与平均ΔPes.ConclusionsVariation内受试者的西格玛RCREC与ΔPes支持以前的证据表明,RCREC在此范围内可能反映微觉醒加剧增加呼吸的工作。在受试者间比较中,β和θ的相关性,而不是σ RCREC与ΔPes的相关性更难解释,但表明σ以外的范围也值得进一步研究以获得临床效用。
Study ObjectivesRespiratory cycle-related EEG changes (RCREC) have been demonstrated during sleep by digital analysis and hypothesized to represent subtle inspiratory microarousals that may help to explain daytime sleepiness in patients with sleep-disordered breathing. We therefore examined for the first time associations between RCREC and esophageal pressure swings (ΔPes) that reflect work of breathing.DesignRetrospective analysisSettingAcademic sleep laboratoryPatientsForty adults referred for suspected sleep disordered breathingInterventionsPolysomnography with esophageal pressure monitoring and automatic computation of ΔPes using a novel algorithm.ResultsComputed ΔPes for nearly all respiratory cycles during sleep correlated well with visual scoring of selected respiratory cycle samples (Spearmanrho= 0.86, P < 0.0001). The RCREC within the sigma EEG range (12.5–15.5 Hz) rather than that within other frequency ranges most often showed significant within-subject inverse correlations with ΔPes. In contrast, in between-subject comparisons, beta (15.5–30.5 Hz) and to a lesser extent theta (4.5–7.5 Hz) RCREC, rather than sigma RCREC, showed significant inverse associations with mean ΔPes.ConclusionsVariation within subjects of sigma RCREC with ΔPes supports previous evidence that RCREC within this range may reflect microarousals exacerbated by increased work of breathing. Correlation of beta and theta, but not sigma RCREC with ΔPes in between-subject comparisons is more difficult to explain but suggests that ranges other than sigma also deserve further investigation for clinical utility.
DOI: 10.1093/sleep/27.1.116
发表时间: 2004-02-01
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影响因子: 5.6
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影响因子: 24.7
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发表时间: 1993-09-01
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影响因子: 9.6
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