The APOL1 gene and allograft survival after kidney transplantation.
The APOL1 gene and allograft survival after kidney transplantation.
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DOI：
10.1111/j.1600-6143.2011.03513.x
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Freedman BI
中科院分区：
文献类型：
--
作者：
Reeves-Daniel AM;DePalma JA;Bleyer AJ;Rocco MV;Murea M;Adams PL;Langefeld CD;Bowden DW;Hicks PJ;Stratta RJ;Lin JJ;Kiger DF;Gautreaux MD;Divers J;Freedman BI
载脂蛋白L1基因（APOL1）编码变异与非裔美国人（AAs）的肾病密切相关。移植两个APOL1肾病风险变异的AA供者肾脏的效果尚不清楚。对106例AA死亡器官供者的APOL1风险变异进行了基因分型，并对136例移植肾的移植存活进行了评估。Cox比例风险模型测试了移植失败时间与供体APOL1基因型之间的关系。平均随访26.4±21.8个月。136个移植肾脏中有22个（16%）来自两种APOL1肾病风险变异的供体。移植失败25例；8例（32%）有2个APOL1风险变异。考虑供体APOL1基因型、整体非洲血统、扩大标准捐赠、受体年龄和性别、HLA错配、CIT和PRA的多变量模型显示，具有两个APOL1风险变异（风险比[HR] 3.84; p=0.008）和更高HLA错配（风险比[HR] 1.52; p=0.03）的供体肾脏移植存活时间明显较短，但不包括APOL1的整体非洲血统的移植存活时间明显较短。患有两种APOL1风险变异的AA已故供者的肾脏在肾移植后比没有或只有一种风险变异的肾脏衰竭得更快。如果重复，APOL1基因分型可以改善供体选择过程，最大限度地提高移植肾的长期存活率。
Coding variants in the apolipoprotein L1 gene (APOL1) are strongly associated with nephropathy in African Americans (AAs). The effect of transplanting kidneys from AA donors with two APOL1 nephropathy risk variants is unknown. APOL1 risk variants were genotyped in 106 AA deceased organ donors and graft survival assessed in 136 resultant kidney transplants. Cox proportional-hazard models tested for association between time to graft failure and donor APOL1 genotypes. Mean follow-up was 26.4 ± 21.8 months. Twenty-two of 136 transplanted kidneys (16%) were from donors with two APOL1 nephropathy risk variants. Twenty five grafts failed; eight (32%) had two APOL1 risk variants. A multivariate model accounting for donor APOL1 genotype, overall African ancestry, expanded criteria donation, recipient age and gender, HLA mismatch, CIT, and PRA revealed that graft survival was significantly shorter in donor kidneys with two APOL1 risk variants (hazard ratio [HR] 3.84; p=0.008) and higher HLA mismatch (HR 1.52; p=0.03), but not for overall African ancestry excluding APOL1. Kidneys from AA deceased donors harboring two APOL1 risk variants failed more rapidly after renal transplantation than those with zero or one risk variants. If replicated, APOL1 genotyping could improve the donor selection process and maximize long term renal allograft survival.
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影响因子：
13.3
作者：
Zhaorigetu S;Wan G;Kaini R;Jiang Z;Hu CA
通讯作者：
Hu CA
DOI：
10.1126/science.1193032
发表时间：
2010-08-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Genovese G;Friedman DJ;Ross MD;Lecordier L;Uzureau P;Freedman BI;Bowden DW;Langefeld CD;Oleksyk TK;Uscinski Knob AL;Bernhardy AJ;Hicks PJ;Nelson GW;Vanhollebeke B;Winkler CA;Kopp JB;Pays E;Pollak MR
通讯作者：
Pollak MR
影响因子：
4.8
作者：
Stannard, AK;Riddell, DR;Owen, JS
通讯作者：
Owen, JS
影响因子：
4.4
作者：
Monajemi, H;Fontijn, RD;Horrevoets, AJG
通讯作者：
Horrevoets, AJG
影响因子：
4.8
作者：
Duchateau, PN;Pullinger, CR;Kane, JP
通讯作者：
Kane, JP