Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats

Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats
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慢性内皮素 A 受体阻断可减弱成年大鼠交感神经系统对盐高血压发展的贡献,但对幼年 Dahl 大鼠无影响

DOI:
10.1111/j.1748-1716.2012.02395.x
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发表时间:
2012
期刊:
影响因子:
6.3
通讯作者:
I. Vaněčková
I. Vaněčková
中科院分区:
医学1区
文献类型:
--
作者:
J. Zicha;Z. Dobešová;J. Kuneš;I. Vaněčková

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内皮素-1(ET-1)在成年大鼠盐依赖性高血压的发病机制中起重要作用,但其在未成年大鼠盐性高血压中的作用尚不清楚。因此,我们比较了ET-1在年轻(4周龄)或成年(12周龄)Dahl大鼠中诱导的盐性高血压的发展或维持中的作用。
Endothelin‐1 (ET‐1) plays an important role in the pathogenesis of salt‐dependent forms of hypertension in adult rats, but its participation in salt hypertension elicited in immature rats is still unknown. Therefore, we compared ET‐1 role in the development or the maintenance of salt hypertension induced in young (4‐week‐old) or adult (12‐week‐old) Dahl rats.
DOI: 10.1161/01.hyp.32.1.59
发表时间: 1998-07-01
期刊: HYPERTENSION
影响因子: 8.3
作者:
Schnackenberg, CG;Welch, WJ;Wilcox, CS
通讯作者: Wilcox, CS