Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES.
Association of serum 25-hydroxyvitamin D levels with all-cause and cause-specific mortality among postmenopausal females: results from NHANES.
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DOI：
10.1186/s12967-023-04413-y
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发表时间：
2023-09-16
影响因子：
7.4
通讯作者：
Li, Ming-Qing
中科院分区：
文献类型：
--
作者：
Shi, Jia-Wei;Wu, Jiang-Nan;Zhu, Xiao-Yong;Zhou, Wen-Hui;Yang, Jin-Ying;Li, Ming-Qing
维生素 D 缺乏症在人群中很常见，但其与绝经后女性死亡率的关系尚不清楚。本研究的目的是探讨美国绝经后妇女血清 25-羟基维生素 D (25(OH)D) 与全因和特定原因死亡率之间的关系。本研究纳入了国家健康与营养检查调查（2001-2018）中的 6812 名绝经后女性参与者。通过与截至 2019 年 12 月 31 日的国家死亡指数 (NDI) 记录的联系来确定随访的死亡率状况。我们使用 cox 比例风险模型来估计血清 25(OH)D 浓度与绝经后女性死亡率的关联。血清 25(OH)D 平均水平为 72.57±29.93 nmol/L，65.34% 的人维生素 D 不足。在绝经后女性中，低血清 25(OH)D 浓度与较高水平的糖化血红蛋白、葡萄糖和较低水平的 HDL 显着相关。在随访期间，发生了 1448 例全因死亡，其中包括 393 例与心血管疾病 (CVD) 相关的死亡和 263 例癌症死亡。经过多变量调整后，较高的血清 25(OH)D 水平与较低的全因死亡率和 CVD 死亡率显着相关。此外，血清25(OH)D与全因死亡率呈L型关系，与CVD死亡率呈U型关系，截止值分别为73.89 nmol/L和46.75 nmol/L。低血清 25(OH)D 水平与绝经后女性全因死亡率和 CVD 死亡率较高相关。这些发现为绝经后妇女的健康管理提供了新的思路和目标。
Vitamin D deficiency is common among the population, but its relationship with mortality of postmenopausal females is unclear. The aim of this study is to explore the association between serum 25-Hydroxyvitamin D (25(OH)D) and all-cause and cause-specific mortality among postmenopausal women in the United States. 6812 participants of postmenopausal females from the National Health and Nutrition Examination Survey (2001–2018) were included in this study. The mortality status of the follow-up was ascertained by linkage to National Death Index (NDI) records through 31 December 2019. We used cox proportional hazards models to estimate the association of serum 25(OH)D concentrations and mortality of postmenopausal females. The mean level of serum 25(OH)D was 72.57 ± 29.93 nmol/L, and 65.34% had insufficient vitamin D. In postmenopausal females, low serum 25(OH)D concentrations were significantly associated with higher levels of glycohemoglobin, glucose, and lower levels of HDL. During follow-up, 1448 all-cause deaths occurred, including 393 cardiovascular disease (CVD)-related deaths and 263 cancer deaths. After multivariate adjustment, higher serum 25(OH)D levels were significantly related with lower all-cause and CVD mortality. In addition, serum 25(OH)D presented a L-shaped relationship with all-cause mortality, while appeared a U-shaped with CVD mortality, and the cut-off value is 73.89 nmol/L and 46.75 nmol/L respectively. Low serum 25(OH)D levels are associated with the higher risk of all-cause and CVD mortality in postmenopausal females. These findings provide new ideas and targets for the health management of postmenopausal women.
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影响因子：
5.4
作者：
Anderson JJ;Kruszka B;Delaney JA;He K;Burke GL;Alonso A;Bild DE;Budoff M;Michos ED
通讯作者：
Michos ED
影响因子：
5.9
作者：
Ames BN;Grant WB;Willett WC
通讯作者：
Willett WC
影响因子：
15.9
作者：
Li, YC;Kong, J;Cao, LP
通讯作者：
Cao, LP
DOI：
10.3945/ajcn.115.120873
发表时间：
2016-04
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Cashman KD;Dowling KG;Škrabáková Z;Gonzalez-Gross M;Valtueña J;De Henauw S;Moreno L;Damsgaard CT;Michaelsen KF;Mølgaard C;Jorde R;Grimnes G;Moschonis G;Mavrogianni C;Manios Y;Thamm M;Mensink GB;Rabenberg M;Busch MA;Cox L;Meadows S;Goldberg G;Prentice A;Dekker JM;Nijpels G;Pilz S;Swart KM;van Schoor NM;Lips P;Eiriksdottir G;Gudnason V;Cotch MF;Koskinen S;Lamberg-Allardt C;Durazo-Arvizu RA;Sempos CT;Kiely M
通讯作者：
Kiely M
影响因子：
5.8
作者：
Chin K;Appel LJ;Michos ED
通讯作者：
Michos ED